Tencheva J, Velinov G, Budevsky O
Arzneimittelforschung. 1979;29(9):1331-4.
A new approach to the graphic extrapolation procedure is proposed for the determination of pK-value of pharmaceuticals poorly soluble in water. It is based on a direct potentiometric method for the determination of acid-base constants in non-aqueous and mixed solvents in which no preliminary calibration of the galvanic cell is needed (glass and calomel electrodes). In this way the applicability of the graphic extrapolation procedure is enlarged for a great number of organic solvents miscible with water for which no buffer pH-standards are available.
提出了一种用于测定难溶于水的药物pK值的图形外推法新方法。它基于一种直接电位法，用于测定非水和混合溶剂中的酸碱常数，在此方法中无需对原电池进行预校准（玻璃电极和甘汞电极）。通过这种方式，图形外推法的适用性扩展到了大量与水混溶的有机溶剂，而对于这些溶剂没有可用的缓冲pH标准液。
