Miholic J, Graninger W, Havel M, Klepetko W, Laufer G, Sandtner W
Thorac Cardiovasc Surg. 1985 Jun;33(3):176-8. doi: 10.1055/s-2007-1014111.
Plasma concentrations of fibronectin, albumin, total protein and IgM were measured in 14 male patients undergoing aorto-coronary bypass operations. Fibronectin and IgM concentrations fell to 55% of the preoperative values 5 minutes after start of the extracorporeal circulation, and the same percentages were encountered 5 minutes after the termination of bypass. The concentrations had recovered to 75% of the preoperative values by the end of the operation. The plasma concentration of albumin was 68 +/- 9% of the preoperative value after 5 minutes of bypass, 66 +/- 7% at the end of bypass, and 83 +/- 9% of the end of operation (significantly different from fibronectin and IgM, p less than 0.05; Wilcoxon's test for paired differences). No correlation was found between the duration of extracorporeal circulation and the post-bypass concentrations of any protein (Kendall correlation). It is concluded that the fall of fibronectin concentrations during cardiopulmonary bypass can be sufficiently explained by dilution, and that a specific consumption of fibronectin does not occur. The less marked decreases of albumin and total protein were probably due to infusion of plasma-protein solution, which is poor in fibronectin and IgM.
对14名接受主动脉冠状动脉搭桥手术的男性患者测量了血浆中纤连蛋白、白蛋白、总蛋白和IgM的浓度。体外循环开始5分钟后，纤连蛋白和IgM浓度降至术前值的55%，搭桥结束5分钟后出现相同百分比。到手术结束时，浓度已恢复到术前值的75%。搭桥5分钟后白蛋白血浆浓度为术前值的68±9%，搭桥结束时为66±7%，手术结束时为83±9%（与纤连蛋白和IgM有显著差异，p<0.05；配对差异的Wilcoxon检验）。未发现体外循环持续时间与任何蛋白质的搭桥后浓度之间存在相关性（Kendall相关性）。得出的结论是，心肺转流期间纤连蛋白浓度的下降可以通过稀释得到充分解释，并且不存在纤连蛋白的特异性消耗。白蛋白和总蛋白下降不太明显可能是由于输注了纤连蛋白和IgM含量较低的血浆蛋白溶液。
