Cavalleri M, Carcano A, Morandi F, Piazza C, Maggioni E, Reni G
Annu Int Conf IEEE Eng Med Biol Soc. 2013;2013:2445-8. doi: 10.1109/EMBC.2013.6610034.
Congenital Central Hypoventilation Syndrome (CCHS) is a genetic disease that causes an autonomous nervous system dysregulation. Patients are unable to have a correct ventilation, especially during sleep, facing risk of death. Therefore, most of them are mechanically ventilated during night and their blood oxygenation is monitored, while a supervisor keeps watch over them. If low oxygen levels are detected by the pulse-oximeter, an alarm fires; the supervisor deals with the situation and, if there is neither a technical problem nor a false alarm, wakes the subject, as CCHS patients usually recover from hypoxia when roused from sleep. During a single night multiple alarms may occur, causing fractioned sleep for the subject and a lasting state of anxiety for supervisors.
先天性中枢性低通气综合征（CCHS）是一种导致自主神经系统调节异常的遗传疾病。患者无法进行正常通气，尤其是在睡眠期间，面临死亡风险。因此，他们中的大多数人在夜间需要机械通气并监测其血液氧合情况，同时有专人进行监护。如果脉搏血氧仪检测到低氧水平，就会发出警报；监护人员处理这种情况，如果既没有技术问题也不是误报，就会唤醒患者，因为CCHS患者通常在从睡眠中被唤醒时会从缺氧状态中恢复。在一个晚上可能会发生多次警报，导致患者睡眠碎片化，监护人员长期处于焦虑状态。
