Hirano Hiroki, Horiuchi Tetsuya, Hirano Harutoyo, Kurita Yuichi, Ukawa Teiji, Nakamura Ryuji, Saeki Noboru, Yoshizumi Masao, Kawamoto Masashi, Tsuji Toshio
Annu Int Conf IEEE Eng Med Biol Soc. 2013;2013:2587-90. doi: 10.1109/EMBC.2013.6610069.
This paper proposes a novel technique to support the monitoring of peripheral vascular conditions using biological signals such as electrocardiograms, arterial pressure values and pulse oximetry plethysmographic waveforms. In this approach, a second-order log-linearized model (referred to here as a log-linearized peripheral arterial viscoelastic model) is used to describe the non-linear viscoelastic relationship between blood pressure waveforms and photo-plethysmographic waveforms. The proposed index enables estimation of peripheral arterial wall stiffness changes induced by sympathetic nerve activity. The validity of the method is discussed here based on the results of peripheral vascular condition monitoring conducted during endoscopic thoracic sympathectomy (ETS). The results of ETS monitoring showed significant changes in stiffness variations between the periods before and during the procedures observed (p < 0.01) as well as during and after them (p < 0.01), so that it was confirmed that sympathetic nerve activity is drastically decreased in the area around the monitoring site after the thoracic sympathetic nerve trunk on the monitoring side is successfully blocked. In addition, no change was observed in the values of the proposed index during the ETS procedure on the side opposite that of the monitoring site. The experimental results obtained clearly show the proposed method can be used to assess changes in sympathetic nerve activity during ETS.
本文提出了一种新技术，用于支持利用生物信号（如心电图、动脉压值和脉搏血氧饱和度容积描记波形）监测外周血管状况。在这种方法中，使用二阶对数线性化模型（在此称为对数线性化外周动脉粘弹性模型）来描述血压波形与光电容积描记波形之间的非线性粘弹性关系。所提出的指标能够估计交感神经活动引起的外周动脉壁僵硬度变化。在此基于内镜胸交感神经切断术（ETS）期间进行的外周血管状况监测结果讨论该方法的有效性。ETS监测结果显示，在观察到的手术前、手术期间以及手术期间和手术后，僵硬度变化存在显著差异（p < 0.01），从而证实监测侧胸交感神经干成功阻断后，监测部位周围区域的交感神经活动急剧下降。此外，在监测部位对侧进行ETS手术期间，所提出指标的值未观察到变化。获得的实验结果清楚地表明，所提出的方法可用于评估ETS期间交感神经活动的变化。
