Ma Heather T, Lv Haiyan, Griffith James F, Yuan Jing, Leung Ping-Chung
Annu Int Conf IEEE Eng Med Biol Soc. 2013;2013:2607-10. doi: 10.1109/EMBC.2013.6610074.
This study investigated bone marrow perfusion at proximal femur varying with bone mineral density (BMD) and aging over 4 years. Dynamic contrast enhanced MRI data was extracted pixel-by-pixel and classified into 3 patterns to indicate the perfusion function. Eighty-seven elderly females were involved. A notable reduced perfusion as a whole was observed in osteoporotic subjects. Moreover, perfusion distribution varies as BMD decreases, especially at the area crossing the femoral neck to the shaft. Consistent for all subjects, the perfusion decreases significantly from the lesser trochanter to the greater trochanter. Further, the subjects with good bone marrow perfusion would keep stable BMD after 4 years, while for those with bad perfusion, their BMD consistently decreased over 4 years. The results indicated that the bone marrow perfusion function interacts with bone modeling and could have a long term effect on BMD. A good perfusion function would help to keep the bone health.
本研究调查了4年间股骨近端骨髓灌注随骨密度（BMD）和衰老的变化情况。动态对比增强MRI数据逐像素提取，并分为3种模式以指示灌注功能。纳入了87名老年女性。骨质疏松受试者整体灌注明显降低。此外，随着BMD降低，灌注分布发生变化，尤其是在股骨颈至骨干的交叉区域。所有受试者一致的是，从小转子到转子间嵴灌注显著降低。此外，骨髓灌注良好的受试者4年后BMD保持稳定，而灌注不良的受试者4年间BMD持续下降。结果表明，骨髓灌注功能与骨建模相互作用，且可能对BMD产生长期影响。良好的灌注功能有助于保持骨骼健康。
