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用近红外光谱法测量长骨血流动力学的理由

The Case for Measuring Long Bone Hemodynamics With Near-Infrared Spectroscopy.

作者信息

Zhang Chuan, McCully Kevin K

机构信息

Department of Kinesiology, University of Georgia, Athens, GA, United States.

出版信息

Front Physiol. 2020 Dec 18;11:615977. doi: 10.3389/fphys.2020.615977. eCollection 2020.

Abstract

Diseases and associated fragility of bone is an important medical issue. There is increasing evidence that bone health is related to blood flow and oxygen delivery. The development of non-invasive methods to evaluate bone blood flow and oxygen delivery promise to improve the detection and treatment of bone health in human. Near-infrared spectroscopy (NIRS) has been used to evaluate oxygen levels, blood flow, and metabolism in skeletal muscle and brain. While the limited penetration depth of NIRS restricts its application, NIRS studies have been performed on the medial aspect of the tibia and some other prominent bone sites. Two approaches using NIRS to evaluate bone health are discussed: (1) the rate of re-oxygenation of bone after a short bout of ischemia, and (2) the dynamics of oxygen levels during an intervention such as resistance exercise. Early studies have shown these approaches to have the potential to evaluate bone vascular health as well as the predicted efficacy of an intervention before changes in bone composition are detectable. Future studies are needed to fully develop and exploit the use of NIRS technology for the study of bone health.

摘要

疾病与相关的骨脆弱性是一个重要的医学问题。越来越多的证据表明,骨骼健康与血流及氧气输送有关。评估骨血流和氧气输送的非侵入性方法的发展有望改善人类骨骼健康的检测与治疗。近红外光谱(NIRS)已被用于评估骨骼肌和大脑中的氧水平、血流及代谢。虽然NIRS有限的穿透深度限制了其应用,但已在胫骨内侧及其他一些突出的骨部位进行了NIRS研究。讨论了使用NIRS评估骨骼健康的两种方法:(1)短时间缺血后骨的再氧合速率,以及(2)诸如抗阻运动等干预过程中氧水平的动态变化。早期研究表明,这些方法有潜力在骨成分变化可检测之前评估骨血管健康以及干预的预期疗效。需要开展进一步研究以充分开发并利用NIRS技术用于骨骼健康研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6063/7775486/18a1a6caf1b4/fphys-11-615977-g001.jpg

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