Luo Yunhua, Leslie William
Annu Int Conf IEEE Eng Med Biol Soc. 2013;2013:3171-4. doi: 10.1109/EMBC.2013.6610214.
DXA (dual energy X-ray absorptiometry) based finite element model is able to integrate all mechanical factors affecting hip fracture in osteoporosis patients and it is thus, in principle, more reliable than areal bone mineral density (BMD) for assessing fracture risk. However, short-term repeatability of DXA-based finite element model in predicting fracture risk has not yet been investigated and satisfactory repeatability is a prerequisite for the procedure to be applied in clinic. Therefore, in the reported research, the repeatability of a previously developed DXA-based patient-specific finite element procedure was investigated. It was found that inconsistence in positioning the patient during DXA scanning and manual segmentation of DXA image in constructing the finite element model are the two dominant factors affecting short-term repeatability of the finite element procedure. The study outcome indicated that to apply the finite element procedure in clinic, a set of more strict guidelines for positioning the patient in DXA scanning must be established and followed.
基于双能X线吸收法（DXA）的有限元模型能够整合影响骨质疏松症患者髋部骨折的所有力学因素，因此，原则上在评估骨折风险方面比骨面积密度（BMD）更可靠。然而，基于DXA的有限元模型在预测骨折风险方面的短期重复性尚未得到研究，而令人满意的重复性是该方法应用于临床的前提条件。因此，在本报告的研究中，对先前开发的基于DXA的患者特异性有限元方法的重复性进行了研究。研究发现，在DXA扫描过程中患者定位不一致以及在构建有限元模型时对DXA图像进行手动分割是影响有限元方法短期重复性的两个主要因素。研究结果表明，要将有限元方法应用于临床，必须建立并遵循一套更严格的DXA扫描患者定位指南。
