Chalacheva Patjanaporn, Khoo Michael C K
Annu Int Conf IEEE Eng Med Biol Soc. 2013;2013:3825-8. doi: 10.1109/EMBC.2013.6610378.
Short-term blood pressure variability is generally attributed to the baroreflex feedback control on heart rate and systemic vascular resistance (SVR), and the mechanical effect of respiration on stroke volume. Although it is known that respiration affects sympathetic outflow and deep breaths can lead to peripheral vasoconstriction, the respiratory modulation of SVR has been little studied. In the present study, we investigated the dynamics resulting from the respiratory modulation of SVR and its effect on blood pressure variability by employing structured and minimal modeling approaches. Using peripheral arterial tonometry as a noninvasive measure of SVR, we were able to estimate the respiratory-vascular conductance coupling mechanism. We found that the dynamics of the sigh-vasoconstriction reflex could be reproduced only when the respiratory modulation of SVR was incorporated into the closed-loop model. Lastly, we demonstrated that taking this respiratory modulation effect into account is essential for accurately estimating the dynamics of the SVR baroreflex.
短期血压变异性通常归因于压力反射对心率和全身血管阻力（SVR）的反馈控制，以及呼吸对每搏输出量的机械作用。尽管已知呼吸会影响交感神经输出，深呼吸可导致外周血管收缩，但对SVR的呼吸调节研究甚少。在本研究中，我们采用结构化和最小化建模方法，研究了SVR呼吸调节产生的动力学及其对血压变异性的影响。使用外周动脉张力测量法作为SVR的非侵入性测量方法，我们能够估计呼吸-血管传导耦合机制。我们发现，只有将SVR的呼吸调节纳入闭环模型，才能重现叹息-血管收缩反射的动力学。最后，我们证明，考虑这种呼吸调节效应对于准确估计SVR压力反射的动力学至关重要。
