一种通过癌基因失活实现CD4 +辅助性T细胞依赖性肿瘤消退的肿瘤免疫数学模型。
A tumor-immune mathematical model of CD4+ T helper cell dependent tumor regression by oncogene inactivation.
作者信息
Nwabugwu Chinyere I, Rakhra Kavya, Felsher Dean W, Paik David S
出版信息
Annu Int Conf IEEE Eng Med Biol Soc. 2013;2013:4529-32. doi: 10.1109/EMBC.2013.6610554.
Abstract
Understanding the complex dynamics between the tumor cells and the host immune system will be key to improved therapeutic strategies against cancer. We propose an ODE-based mathematical model of both the tumor and immune system and how they respond to inactivation of the driving oncogene. Our model supports experimental results showing that cellular senescence of tumor cells is dependent on CD4+ T helper cells, leading to relapse of tumors in immunocompromised hosts.
摘要
了解肿瘤细胞与宿主免疫系统之间的复杂动态关系将是改进癌症治疗策略的关键。我们提出了一个基于常微分方程的肿瘤和免疫系统数学模型，以及它们如何对驱动癌基因的失活做出反应。我们的模型支持实验结果，即肿瘤细胞的细胞衰老依赖于CD4 +辅助性T细胞，导致免疫功能低下宿主中的肿瘤复发。
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