Rystedt I
Acta Derm Venereol. 1985;65(3):206-13.
A long-term follow-up study (24 years minimum) was made of 955 individuals aged 24-44 years, who had atopic dermatitis (AD) in childhood. The material was divided into two groups; patients who in 1952-56 had been hospitalized on at least one occasion at the Department of Dermatology, Karolinska Hospital, Stockholm (Group 1), and patients who in 1955-56 had been out-patients in the same department (Group 2). At the time of investigation 62% and 40% of the patients in Groups 1 and 2 respectively had ongoing dermatitis, the majority with mild skin lesions. The frequency of healing of AD and severity of persistent or recurring dermatitis were influenced by several factors. In order of relative importance, disregarding sampling errors, persistent dry/itchy skin in adult life, widespread dermatitis in childhood, associated allergic rhinitis, family history of AD, associated bronchial asthma, early age at onset, and female sex were associated with low frequency of healing and increased severity of persistent or recurring dermatitis.
对955名曾在儿童期患特应性皮炎（AD）的24至44岁个体进行了一项长期随访研究（至少24年）。研究对象分为两组：1952 - 1956年期间至少有一次在斯德哥尔摩卡罗林斯卡医院皮肤科住院治疗的患者（第1组），以及1955 - 1956年期间在同一科室门诊就诊的患者（第2组）。在调查时，第1组和第2组分别有62%和40%的患者仍患有皮炎，大多数患者皮肤病变较轻。特应性皮炎的愈合频率以及持续性或复发性皮炎的严重程度受多种因素影响。不考虑抽样误差，按相对重要性排序，成年后持续存在的皮肤干燥/瘙痒、儿童期广泛的皮炎、伴发的过敏性鼻炎、特应性皮炎家族史、伴发的支气管哮喘、发病年龄早以及女性性别与愈合频率低和持续性或复发性皮炎严重程度增加有关。
