Samochocki Z, Paulochowska E, Zabielski S
Department of Dermatology, Center of Postgraduate Medical Education, Warsaw, Poland.
J Med. 2000;31(3-4):177-82.
Prognostication of the course of atopic dermatitis (AD) is of special importance in prophylaxis of this disease. The aim of the study was to describe the AD minor feature sets, according to Hanifin and Rajka, on the basis of which one can predict the occurrence of extensive skin lesions, allergic rhinitis, atopic bronchial asthma, cataracts, hand and/or foot dermatitis, food intolerance, urticaria and elevated IgE serum in AD patients. Two-hundred-fifty-four patients were included in the study. Minor feature sets of prognostic value were selected using the MANOVA method in conjunction with the discriminant analysis. On the basis of the above sets, one can predict: involvement of more than 60% of body surface, occurrence of allergic rhinitis, elevated serum IgE, cataracts, atopic bronchial asthma, food intolerance and urticaria with the probability ratio of 90.8%, 82.8%, 79.9%, 78.4%, 77.3%, 77.1% and 76.1% respectively. In the examined group, no association was found between hand and/or foot dermatitis and the tendency towards skin infection.
特应性皮炎（AD）病程的预后判断对该疾病的预防尤为重要。本研究旨在根据Hanifin和Rajka的标准描述AD的次要特征集，据此可以预测AD患者广泛皮肤病变、过敏性鼻炎、特应性支气管哮喘、白内障、手足皮炎、食物不耐受、荨麻疹及血清IgE升高的发生情况。本研究纳入了254例患者。采用多变量方差分析（MANOVA）结合判别分析的方法选择具有预后价值的次要特征集。基于上述特征集，可以分别以90.8%、82.8%、79.9%、78.4%、77.3%、77.1%和76.1%的概率比预测：体表面积受累超过60%、过敏性鼻炎的发生、血清IgE升高、白内障、特应性支气管哮喘、食物不耐受和荨麻疹。在研究组中，未发现手足皮炎与皮肤感染倾向之间存在关联。
