Thio Tzer Hwai Gilbert, Ibrahim Fatimah, Al-Faqheri Wisam, Soin Norhayati, Abdul Kahar Maria Kahar Bador, Madou Marc
Annu Int Conf IEEE Eng Med Biol Soc. 2013;2013:5513-6. doi: 10.1109/EMBC.2013.6610798.
Thermo-pneumatic (TP) pumping is a method employing the principle of expanding heated air to transfer fluids back towards the CD center on the centrifugal microfluidic CD platform. While the TP features are easy to fabricate as no moving parts are involved, it consumes extra real estate on the CD, and because heating is involved, it introduces unnecessary heating to the fluids on the CD. To overcome these limitations, we introduce a multi-level 3D approach and implement forced convection heating. In a multi-level 3D CD, the TP features are relocated to a separate top level, while the microfluidic process remains on a lower bottom level. This allows for heat shielding of the fluids in the microfluidic process level, and also improve usage of space on the CD. To aid in future implementations of TP pumping on a multi-level 3D CD, studies on the effect of heat source setting, and the effect of positioning the TP feature (it distance from the CD center) on CD surface heating are also presented. In this work, we successfully demonstrate a multi-level 3D approach to implement TP pumping on the microfluidic CD platform.
热气动（TP）泵送是一种利用热空气膨胀原理将流体向离心式微流控光盘平台上的光盘中心反向传输的方法。虽然TP功能由于不涉及移动部件而易于制造，但它会在光盘上占用额外空间，并且由于涉及加热，会给光盘上的流体带来不必要的热量。为了克服这些限制，我们引入了一种多层3D方法并实施强制对流加热。在多层3D光盘中，TP功能被重新定位到单独的顶层，而微流控过程则保留在较低的底层。这既可以对微流控过程层中的流体进行热屏蔽，又能提高光盘上的空间利用率。为了帮助未来在多层3D光盘上实现TP泵送，还介绍了关于热源设置的影响以及TP功能在光盘表面加热上的定位（其与光盘中心的距离）的影响的研究。在这项工作中，我们成功展示了一种在微流控光盘平台上实现TP泵送的多层3D方法。
