Palladino Joseph L
Annu Int Conf IEEE Eng Med Biol Soc. 2013;2013:7176-9. doi: 10.1109/EMBC.2013.6611213.
A recent functional model of the left ventricle as a pressure generator that is time and volume dependent was adapted to describe the mechanical aspects of heart muscle contraction. Muscle's complex dynamics develop from a single equation based on the formation and relaxation of crossbridge bonds. Muscle is modeled as a force generator that is time and length dependent. This equation permits the calculation of muscle elastance via Em = ∂fm/∂lm from muscle force and length, both as functions of time. This muscle model is defined independently from load properties, and elastance is dynamic and reflects changing numbers of crossbridge bonds. The model parameters were extracted from measured force and length data from cat papillary muscle experiments in the literature. The purpose of this paper is to present in some detail how to describe a particular muscle strip from measured data. The resulting model is tested under a wide range of mechanical conditions, such as isometric and isotonic contractions for normal and varied inotropic state, and muscle velocity is computed for different loads. Computed results compare favorably with similar measurements from the literature. The resulting lumped muscle model is a compact, yet comprehensive functional description of muscle dynamics.
最近，一种将左心室视为与时间和容积相关的压力发生器的功能模型被用于描述心肌收缩的力学方面。肌肉的复杂动力学源于基于横桥键形成和松弛的单一方程。肌肉被建模为与时间和长度相关的力发生器。该方程允许通过Em = ∂fm/∂lm从作为时间函数的肌肉力和长度来计算肌肉弹性。这个肌肉模型独立于负荷特性进行定义，并且弹性是动态的，反映了横桥键数量的变化。模型参数从文献中猫乳头肌实验的测量力和长度数据中提取。本文的目的是详细介绍如何根据测量数据描述特定的肌肉条带。所得模型在广泛的力学条件下进行测试，例如正常和不同变力状态下的等长和等张收缩，并针对不同负荷计算肌肉速度。计算结果与文献中的类似测量结果相比具有优势。所得的集总肌肉模型是对肌肉动力学的一种紧凑而全面的功能描述。
