Palladino Joseph L
Annu Int Conf IEEE Eng Med Biol Soc. 2020 Jul;2020:2311-2314. doi: 10.1109/EMBC44109.2020.9176436.
Models of muscle contraction are typically based on a measured force-velocity relation embodied as Hill's contractile element [1]. Adopting a particular force-velocity relation dictates the muscle's mechanical properties. Dynamic crossbridge based models, such as Huxley's [2], typically focus on ultrastructural mechanics. This study adapts a dynamic lumped model of cardiac muscle contraction [3] for description of mouse soleus skeletal muscle. This compact, dynamic model exhibits the main features of skeletal muscle contraction with few assumptions. The main differences between cardiac and skeletal muscle dynamics are described. This approach gives one equation and set of parameters capable of modeling isometric and isotonic contractions, skeletal muscle's force-length relation, variations in contractility, and the force-velocity relation. This new constitutive equation may be useful for modeling striated muscle as part of larger biomechanical models.
肌肉收缩模型通常基于以希尔收缩元件体现的测量到的力-速度关系[1]。采用特定的力-速度关系决定了肌肉的力学特性。基于动态横桥的模型，如赫胥黎的模型[2]，通常关注超微结构力学。本研究采用一种心肌收缩的动态集总模型[3]来描述小鼠比目鱼肌骨骼肌。这个紧凑的动态模型在假设很少的情况下展现了骨骼肌收缩的主要特征。描述了心肌和骨骼肌动力学之间的主要差异。这种方法给出了一个方程和一组参数，能够对等长收缩和等张收缩、骨骼肌的力-长度关系、收缩性变化以及力-速度关系进行建模。这个新的本构方程可能有助于将横纹肌作为更大生物力学模型的一部分进行建模。
