Khokhar Nasir, Niazi Tariq Khan, Qureshi Muhammad Omar
Department of Gastroenterology / Medicine, Shifa International Hospital, Islamabad.
J Coll Physicians Surg Pak. 2013 Oct;23(10):699-702. doi: 10.2013/JCPSP.699702.
To determine the frequency of development of hepatocellular carcinoma in patients with chronic liver disease secondary to hepatitis C who had achieved sustained virological response with Interferon and Ribavirin therapy.
Retrospective descriptive study.
Shifa International Hospital, Islamabad, Pakistan, from January 2007 to January 2012.
Hepatitis C related chronic liver disease patients who were treated with interferon and ribavirin, after they achieved sustained virological response, they were followed for a mean of 42 ± 17 months. During this time, development of hepatocellular carcinoma was ascertained. All underwent surveillance with alpha-feto-protein and ultrasonography every 6 months.
Out of the 58 patients who had achieved sustained virological response, 3 developed hepatocellular carcinoma after a mean follow-up of 38 ± 14 months. It was multifocal in 2 cases and was single lesion in the 3rd. Two patients ultimately died, one with upper GI bleeding and the other with hepatic encephalopathy, while 3rd patient with single lesion is still surviving.
Three out of 58 patients of hepatitis C related chronic liver disease developed hepatocellular carcinoma during follow-up in patients who had achieved sustained virological response. These patients need closer follow-up, for development of complications, even if they have achieved sustained viral response.
确定丙型肝炎继发慢性肝病患者在接受干扰素和利巴韦林治疗后获得持续病毒学应答时肝细胞癌的发生频率。
回顾性描述性研究。
2007年1月至2012年1月，巴基斯坦伊斯兰堡的希法国际医院。
对接受干扰素和利巴韦林治疗的丙型肝炎相关慢性肝病患者，在其获得持续病毒学应答后，平均随访42±17个月。在此期间，确定肝细胞癌的发生情况。所有患者每6个月接受甲胎蛋白和超声检查进行监测。
在58例获得持续病毒学应答的患者中，3例在平均随访38±14个月后发生肝细胞癌。2例为多灶性，第3例为单发病灶。2例患者最终死亡，1例死于上消化道出血，另1例死于肝性脑病，而第3例单发病灶患者仍存活。
58例丙型肝炎相关慢性肝病患者中有3例在获得持续病毒学应答的患者随访期间发生肝细胞癌。这些患者即使已获得持续病毒应答，也需要密切随访以防并发症的发生。
