Laurent R, Prost O, Nicollier M, Marquet S C, Balzer M M, Adessi G
Arch Dermatol Res. 1985;277(5):384-94. doi: 10.1007/BF00509238.
We report the results of an ultrastructural study of the hyperkeratotic epidermis in 23 cases of palmoplantar keratoderma (PPK) comprising 8 inherited keratoderma, 8 keratoderma climactericum in menopausal women and 7 symptomatic keratoderma. In all but one of the cases of inherited PPK and keratoderma climactericum, composite keratohyalin (KH) granules were found in granular cells of the interductal epidermis, which were similar to those found in the rat and in some other conditions. In the cases of symptomatic keratoderma, e.g. secondary to eczema, the appearance of the KH granules did not differ from that of granules observed in two normal plantar skin samples. While the real role played by these granules is unknown, they could constitute a differentiation marker of intraepidermal duct cells, and their abundance in PPK suggest that intraepidermal sweat ducts may play a part in PPK histogenesis.
我们报告了对23例掌跖角化病（PPK）患者的角化过度表皮进行超微结构研究的结果，其中包括8例遗传性角化病、8例绝经后女性的更年期角化病和7例症状性角化病。除1例遗传性PPK和更年期角化病外，在所有病例的导管间表皮颗粒细胞中均发现了复合角蛋白透明颗粒（KH），这些颗粒与在大鼠及其他一些情况下发现的颗粒相似。在症状性角化病病例中，如继发于湿疹的病例，KH颗粒的外观与在两个正常足底皮肤样本中观察到的颗粒无异。虽然这些颗粒所起的实际作用尚不清楚，但它们可能构成表皮内导管细胞的分化标志物，并且它们在PPK中的丰富程度表明表皮内汗腺导管可能参与了PPK的组织发生。
