Bayo Juan, Marrodán Mariano, Aquino Jorge B, Silva Marcelo, García Mariana G, Mazzolini Guillermo
Gene Therapy Laboratory, Facultad de Ciencias Biomédicas, Universidad Austral, Derqui-Pilar, Argentina.
Liver Int. 2014 Mar;34(3):330-42. doi: 10.1111/liv.12338. Epub 2013 Oct 21.
Mesenchymal stromal cells (MSCs) are more often obtained from adult and extraembryonic tissues, with the latter sources being likely better from a therapeutic perspective. MSCs show tropism towards inflamed or tumourigenic sites. Mechanisms involved in MSC recruitment into tumours are comprehensively analysed, including chemoattractant signalling axes, endothelial adhesion and transmigration. In addition, signals derived from hepatocellular carcinoma (HCC) tumour microenvironment and their influence in MSC tropism and tumour recruitment are dissected, as well as the present controversy regarding their influence on tumour growth and/or metastasis. Finally, evidences available on the use of MSCs and other selected progenitor/stem cells as vehicles of antitumourigenic genes are discussed. A better knowledge of the mechanisms involved in progenitor/stem cell recruitment to HCC tumours is proposed in order to enhance their tumour targeting which may result in improvements in cell-based gene therapy strategies.
间充质基质细胞（MSCs）更多地取自成人和胚外组织，从治疗角度来看，后者来源可能更好。MSCs表现出对炎症或致瘤部位的趋向性。全面分析了MSCs募集到肿瘤中的机制，包括趋化因子信号轴、内皮细胞黏附和迁移。此外，剖析了源自肝细胞癌（HCC）肿瘤微环境的信号及其对MSCs趋向性和肿瘤募集的影响，以及目前关于它们对肿瘤生长和/或转移影响的争议。最后，讨论了关于使用MSCs和其他选定的祖细胞/干细胞作为抗肿瘤基因载体的现有证据。为了增强它们的肿瘤靶向性，从而可能改善基于细胞的基因治疗策略，建议更好地了解祖细胞/干细胞募集到HCC肿瘤中的机制。
