Ishihara Y, Uchida Y, Kitamura S, Takaku F
Arzneimittelforschung. 1985;35(6):929-33.
In the present investigation, the effect of coenzyme Q10 (E-0216) on histamine or SRS-A (slow-reacting substance of anaphylaxis) release from passively sensitized guinea pig lung tissue and on the actions of various bronchoactive-agents in isolated perfused guinea pig tracheal strips was studied. The amount of histamine and SRS-A released from passively sensitized guinea pig lung tissue by the challenge of antigen showed a marked decrease by preincubating with coenzyme Q10. The percentage inhibition of histamine and SRS-A was biggest at the concentration of 10 micrograms/ml of coenzyme Q10. Prostaglandin F2 alpha-, acetylcholine-, serotonin-, and bradykinin-induced contractile responses in guinea pig tracheal strips did not show any significant increase by continuous infusion of coenzyme Q10 (0.05-5.0 micrograms/ml). On the other hand, histamine-induced contractile responses showed a significant increase by continuous infusion of 0.5 microgram/ml of coenzyme Q10. Isoprenaline (isoproterenol)- and salbutamol-induced relaxation responses in guinea pig tracheal strips did not show any significant decrease by continuous infusion of coenzyme Q10 (0.05-5.0 micrograms/ml). On the other hand, prostaglandin E2-induced relaxation responses showed a significant decrease by continuous infusion 0.05-5.0 micrograms/ml of coenzyme Q10.
在本研究中，研究了辅酶Q10（E - 0216）对被动致敏豚鼠肺组织中组胺或过敏反应慢反应物质（SRS - A）释放的影响，以及对离体灌注豚鼠气管条中各种支气管活性剂作用的影响。通过抗原激发，被动致敏豚鼠肺组织释放的组胺和SRS - A量，在与辅酶Q10预孵育后显著降低。在辅酶Q10浓度为10微克/毫升时，组胺和SRS - A的抑制百分比最大。连续输注辅酶Q10（0.05 - 5.0微克/毫升），未使豚鼠气管条中前列腺素F2α、乙酰胆碱、5 - 羟色胺和缓激肽诱导的收缩反应显著增强。另一方面，连续输注0.5微克/毫升的辅酶Q10，使组胺诱导的收缩反应显著增强。连续输注辅酶Q10（0.05 - 5.0微克/毫升），未使豚鼠气管条中异丙肾上腺素和沙丁胺醇诱导的舒张反应显著减弱。另一方面，连续输注0.05 - 5.0微克/毫升的辅酶Q10，使前列腺素E2诱导的舒张反应显著减弱。
