Zandi Mohammad, Dehghan Arash, Saleh Majid, Seyed Hoseini Seyed Rohallah
Department of Oral and Maxillofacial Surgery (Head: Mohammad Zandi, DDS, MSc.), Hamedan University of Medical Sciences, Hamedan, Iran.
Department of Pathology (Head: Alireza Monsef, MD, APCP), Hamedan University of Medical Sciences, Hamedan, Iran.
J Craniomaxillofac Surg. 2014 Jul;42(5):e204-9. doi: 10.1016/j.jcms.2013.08.008. Epub 2013 Sep 13.
To develop a treatment plan for cases in which a bone defect is located on the osteotomy line of mandibular osteodistraction (DO).
Bilateral DO was performed in 17 Mongrel dogs. Prior to surgery, the 34 hemi-mandibles were randomly allocated to three groups: C (n = 10; a standard DO was performed), D - G (n = 12; a bone defect was created on the DO osteotomy line), and D + G (n = 12; the bone defect on the osteotomy line was grafted). After one week of latency, 8 days of distraction, and 4 weeks of consolidation the animals were sacrificed, and the newly formed bone were examined.
In group C, two zones of immature trabecular bone originating from host bone margins were separated by a central fibrous zone. In group D + G uniform new bone formation of the entire distraction gap was observed. In group D - G the distraction gap was mainly filled with fibrous tissue. The values for the newly formed bone volume and trabecular thickness were not significantly different between groups D + G and C, but were higher than values in group D - G (p < 0.05).
When a mandibular defect is located at the site of distraction osteotomy, DO can be performed simultaneous with bone grafting of the defect.
为下颌骨牵张成骨术（DO）截骨线上存在骨缺损的病例制定治疗方案。
对17只杂种犬进行双侧DO。术前，将34侧半下颌骨随机分为三组：C组（n = 10；行标准DO）、D - G组（n = 12；在DO截骨线上制造骨缺损）和D + G组（n = 12；在截骨线上的骨缺损处植骨）。经过1周的延迟期、8天的牵张期和4周的巩固期后，处死动物并检查新形成的骨组织。
C组中，源自宿主骨边缘的两个未成熟小梁骨区域被中央纤维区隔开。D + G组观察到整个牵张间隙有均匀的新骨形成。D - G组牵张间隙主要被纤维组织填充。D + G组和C组新形成骨体积和小梁厚度的值无显著差异，但高于D - G组的值（p < 0.05）。
当下颌骨缺损位于牵张截骨部位时，可在进行骨缺损植骨的同时进行DO。
