干细胞疗法促进牵张成骨中的骨愈合：实验研究的当代综述
Stem cell therapy for enhancement of bone consolidation in distraction osteogenesis: A contemporary review of experimental studies.
作者信息
Yang Y, Lin S, Wang B, Gu W, Li G
机构信息
Department of Key Laboratory, Changzhou No.7 People's Hospital, No. 288 Yanling East Road, Changzhou, Jiangsu, China.
Department of Orthopaedics and Traumatology, Lui Che Woo Institute of Innovative Medicine, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, 30-32 Ngan Shing Street, Prince of Wales Hospital, Shatin, NT, Hong Kong, China.
出版信息
Bone Joint Res. 2017 Jun;6(6):385-390. doi: 10.1302/2046-3758.66.BJR-2017-0023.
OBJECTIVES
Distraction osteogenesis (DO) mobilises bone regenerative potential and avoids the complications of other treatments such as bone graft. The major disadvantage of DO is the length of time required for bone consolidation. Mesenchymal stem cells (MSCs) have been used to promote bone formation with some good results.
METHODS
We hereby review the published literature on the use of MSCs in promoting bone consolidation during DO.
RESULTS
Studies differed in animal type (mice, rabbit, dog, sheep), bone type (femur, tibia, skull), DO protocols and cell transplantation methods.
CONCLUSION
The majority of studies reported that the transplantation of MSCs enhanced bone consolidation or formation in DO. Many questions relating to animal model, DO protocol and cell transplantation regime remain to be further investigated. Clinical trials are needed to test and confirm these findings from animal studies. Y. Yang, S. Lin, B. Wang, W. Gu, G. Li. Stem cell therapy for enhancement of bone consolidation in distraction osteogenesis: A contemporary review of experimental studies. 2017;6:385-390. DOI: 10.1302/2046-3758.66.BJR-2017-0023.
目的
牵张成骨术（DO）可激发骨再生潜能，并避免诸如骨移植等其他治疗方法的并发症。DO的主要缺点是骨巩固所需的时间。间充质干细胞（MSCs）已被用于促进骨形成，且取得了一些良好的效果。
方法
我们在此回顾已发表的关于在DO过程中使用MSCs促进骨巩固的文献。
结果
各研究在动物类型（小鼠、兔子、狗、绵羊）、骨类型（股骨、胫骨、颅骨）、DO方案和细胞移植方法上存在差异。
结论
大多数研究报告称，MSCs移植可增强DO中的骨巩固或骨形成。许多与动物模型、DO方案和细胞移植方案相关的问题仍有待进一步研究。需要进行临床试验来检验和证实这些动物研究的结果。Y. Yang、S. Lin、B. Wang、W. Gu、G. Li。干细胞疗法促进牵张成骨术中的骨巩固：实验研究的当代综述。2017年；6：385 - 390。DOI：10.1302/2046 - 3758.66.BJR - 2017 - 0023。
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