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多关节炎大鼠脊髓中P物质、生长抑素、血管活性肠肽和胆囊收缩素样水平

Substance P-, somatostatin-, vasoactive intestinal peptide- and cholecystokinin-like levels in the spinal cord of polyarthritic rats.

作者信息

Chery-Croze S, Kocher L, Bernard C, Chayvialle J A

出版信息

Brain Res. 1985 Jul 22;339(1):183-5. doi: 10.1016/0006-8993(85)90642-0.

DOI:10.1016/0006-8993(85)90642-0
PMID:2411344
Abstract

Substance P-, somatostatin-, vasoactive intestinal polypeptide- and cholecystokinin-like levels were measured in lumbar dorsal and ventral cord of polyarthritic rats and compared with those obtained in vehicle-treated rats taken as controls. Polyarthritis decreased substance P concentration in lumbar ventral cord and increased cholecystokinin level in lumbar dorsal cord, while the other two peptides did not show any change. The results are discussed in relation to immunohistochemical data found in the literature.

摘要

在多关节炎大鼠的腰段脊髓背侧和腹侧测量了P物质、生长抑素、血管活性肠肽和胆囊收缩素样水平,并与作为对照的接受赋形剂处理的大鼠所测得的水平进行比较。多关节炎降低了腰段脊髓腹侧的P物质浓度,增加了腰段脊髓背侧的胆囊收缩素水平,而其他两种肽未显示任何变化。结合文献中发现的免疫组织化学数据对结果进行了讨论。

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Bombesin stimulates cholecystokinin secretion through mitogen-activated protein-kinase-dependent and -independent mechanisms in the enteroendocrine STC-1 cell line.蛙皮素通过有丝分裂原激活蛋白激酶依赖性和非依赖性机制刺激肠内分泌STC-1细胞系中的胆囊收缩素分泌。
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