Oku R, Satoh M, Takagi H
Neurosci Lett. 1987 Mar 9;74(3):315-9. doi: 10.1016/0304-3940(87)90316-8.
Using in situ spinal dorsal horn perfusing method in decerebrated rats, we measured the release of immunoreactive substance P (iSP) in polyarthritic rats. The spontaneous release of iSP from the dorsal horn in the polyarthritic rats was significantly accelerated over that in control non-inflamed rats. Passive movements of the inflamed ankle joint evoked a significant increase in the release of iSP, while a similar movement of the non-inflamed joint led to no such increase. These results suggest that the facilitated release of iSP from the primary afferent terminals in the spinal dorsal horn in polyarthritic rats possibly plays a role in transmission of chronic pain of inflamed joints.
我们采用去大脑大鼠原位脊髓背角灌流法，测定了多关节炎大鼠中免疫反应性P物质（iSP）的释放。多关节炎大鼠背角中iSP的自发释放比对照未发炎大鼠显著加快。发炎踝关节的被动运动引起iSP释放显著增加，而未发炎关节的类似运动则未导致这种增加。这些结果表明，多关节炎大鼠脊髓背角初级传入终末iSP释放的促进可能在发炎关节慢性疼痛的传递中起作用。
