照射后大鼠胰腺中的水解活性。
Hydro-proteolytic activity in rat's pancreas after irradiation.
作者信息
Koćmierska-Grodzka D, Radwan J
出版信息
Strahlentherapie. 1975 Jul;150(1):80-6.
Investigations were carried out on the problem of hydrolytic ability of rat's pancreas 24 h after whole body irradiation with the single dose of 800 R and after fractionated irradiation (5 x 150 R). Besides kallikrein, enzymes of intracellular digestion (B-glucuronidase, acid phosphatase, cathepsin) and enzymes of intraluminal digestion (amylase, lipase) were chosed for examination. It was stated, that single irradiation evokes rather moderate changes in the activity of examined enzymes causing increase of catheptic and lipolytic activity and decrease in amylase activity accompanied by sharp increase of kallikrein activity in the tissue. Mechanical obstruction of biliopancreatic duct renders trend to decrease of enzymatic activity in almost all enzymes of irradiated group. After fractionated irradiation the general increase of hydroproteolytic activity (with one exception of pancreatic amylase) was stated.
对大鼠全身单次照射800伦琴及分次照射（5×150伦琴）24小时后胰腺水解能力问题进行了研究。除激肽释放酶外，还选择了细胞内消化酶（β-葡萄糖醛酸酶、酸性磷酸酶、组织蛋白酶）和管腔内消化酶（淀粉酶、脂肪酶）进行检测。结果表明，单次照射引起所检测酶活性的变化较为温和，导致组织蛋白酶活性和脂解活性增加，淀粉酶活性降低，同时激肽释放酶活性急剧增加。胆胰管机械性梗阻使照射组几乎所有酶的活性都有降低趋势。分次照射后，除胰淀粉酶外，水解蛋白活性普遍增加。
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