Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia.
Mol Carcinog. 2014 Feb;53 Suppl 1:E193-200. doi: 10.1002/mc.22086. Epub 2013 Sep 21.
A single nucleotide polymorphism (SNP), rs6983267, in the chromosome 8q24 region, has been associated with higher risk for colorectal neoplasms, but its relation to carcinogenic mechanisms is unclear. To investigate whether associations of colorectal adenoma with its major modifiable risk factors differ according to rs6983267 genotype, we performed a pooled analysis of the White participants (n = 401 cases, 518 controls) from three colonoscopy-based, case-control studies of incident, sporadic colorectal adenoma conducted between 1991 and 2002. There was a statistically significant direct association of rs6983267 with colorectal adenoma that was consistent with those in previous reports. We found no clear indications that rs6983267 impacts the association of colorectal adenomas with the following risk factors: physical activity, body mass index (BMI), nonsteroidal anti-inflammatory drug (NSAID) use, tobacco or alcohol use, hormone replacement therapy among women, blood 25-OH-vitamin D3 levels, oxidative balance, or total energy, calcium, red meat, vegetable and fruit, and folate intakes. These findings, together with previously reported null results on 8q24-environment interactions for colorectal cancer, suggest that associations of colorectal adenoma with its major modifiable risk factors may not differ according to chromosome 8q24 region rs6983267 genotype.
单个核苷酸多态性（SNP）rs6983267 位于 8q24 染色体区域，与结直肠肿瘤的风险增加有关，但与致癌机制的关系尚不清楚。为了研究 rs6983267 基因型是否与结直肠腺瘤的主要可调节危险因素的关联不同，我们对 1991 年至 2002 年间进行的三项基于结肠镜检查的、针对偶发性散发性结直肠腺瘤的病例对照研究中的白人参与者（n = 401 例病例，518 例对照）进行了汇总分析。rs6983267 与结直肠腺瘤之间存在统计学上显著的直接关联，与先前的报告一致。我们没有明确的迹象表明 rs6983267 影响结直肠腺瘤与以下危险因素的关联：体力活动、体重指数（BMI）、非甾体抗炎药（NSAID）使用、烟草或酒精使用、女性激素替代疗法、血液 25-OH-维生素 D3 水平、氧化平衡或总能量、钙、红肉、蔬菜和水果以及叶酸摄入量。这些发现，以及先前报道的 8q24 环境与结直肠癌相互作用的阴性结果，表明结直肠腺瘤与主要可调节危险因素的关联可能不会因染色体 8q24 区域 rs6983267 基因型而异。
