Iyoke Ca, Ugwu Go, Ezugwu Ec, Onah N, Ugwu O, Okafor O
Department of Obstetrics and Gynecology, University of Nigeria Teaching Hospital, Ituku-Ozalla, Nigeria.
Ann Med Health Sci Res. 2013 Jul;3(3):417-21. doi: 10.4103/2141-9248.117947.
The incidence of ovarian cancer is thought to be increasing in developing countries and little is known about the pattern and incidence of this disease in South-East Nigeria.
The objectives of the study were to determine the incidence, describe the pattern and management of ovarian cancer at a tertiary medical center in Enugu South East Nigeria.
This was a retrospective review of cases of histologically diagnosed primary ovarian cancer at the study center over 11 years. Cases of histologically diagnosed primary ovarian cancer were identified through the records of the study center cancer registry and confirmed from the records of the histopathology department. Case notes, admission and theatre records were used to obtain data relating to clinical management, mortality and incidence of primary ovarian cancer. Statistical analysis was dose using SPSS statistical software version 17.0 for windows. Descriptive and inferential statistics were applied to obtain rates, proportions and 95% confidence intervals for these estimates.
There were 20,227 gynecological admissions during the study period (from January 2000 to December 2010) and 206 gynecological cancers. There were 54 cases of primary ovarian cancer giving an incidence rate of 1/405 gynecological admissions per year or 0.3% (95% confidential interval [CI] 0.23%, 0.38%) or 2.4% (54/206) per gynecological cancer per year. Epithelial ovarian cancer constituted 68% of cases of ovarian cancer (95% CI 54%, 82%): Sex cord and germ cell tumors constituted 16% each (95% CI 6%, 26%). Approximately 60% of women who had epithelial ovarian cancer were aged 50 years or below (95% CI 47%, 74%) and 72% of epithelial ovarian cancer occurred in multiparous women (95% CI 72.1%, 91.9%). Over 84% of ovarian cancer presented in stages 3 and 4 of the disease (95% CI 94%, 72%). The mainstay of management was surgery: Compliance with cis-platinum based adjuvant chemotherapy was poor. Case-specific mortality rate within 1 year of diagnosis was, at least, 70% (95% CI 64%, 84%).
Primary ovarian cancer was uncommon and consisted mainly of epithelial cancer. Epithelial ovarian cancer occurred more in multiparous women and in women under 50 years in our center contrary to the known pattern of the disease.
在发展中国家，卵巢癌的发病率被认为正在上升，而关于尼日利亚东南部这种疾病的发病模式和发病率知之甚少。
本研究的目的是确定尼日利亚东南部埃努古一家三级医疗中心卵巢癌的发病率，描述其发病模式及治疗情况。
这是一项对研究中心11年间经组织学诊断的原发性卵巢癌病例的回顾性研究。通过研究中心癌症登记处的记录识别经组织学诊断的原发性卵巢癌病例，并从组织病理学部门的记录中予以确认。使用病例记录、入院和手术记录来获取与原发性卵巢癌临床治疗、死亡率和发病率相关的数据。使用适用于Windows的SPSS统计软件版本17.0进行统计分析。应用描述性和推断性统计来获得这些估计值的发生率、比例和95%置信区间。
在研究期间（2000年1月至2010年12月）有20227例妇科住院病例，其中妇科癌症206例。原发性卵巢癌病例54例，发病率为每年每405例妇科住院病例中有1例，即0.3%（95%置信区间[CI]0.23%，0.38%），或每年每例妇科癌症中有2.4%（54/206）。上皮性卵巢癌占卵巢癌病例的68%（95%CI54%，82%）：性索和生殖细胞肿瘤各占16%（95%CI6%，26%）。约60%的上皮性卵巢癌女性年龄在50岁及以下（95%CI47%，74%），72%的上皮性卵巢癌发生在多产妇女中（95%CI72.1%，91.9%）。超过84%的卵巢癌在疾病的3期和4期出现（95%CI94%，72%）。主要治疗方法是手术：顺铂辅助化疗的依从性较差。诊断后1年内的病例特异性死亡率至少为70%（95%CI64%，84%）。
原发性卵巢癌并不常见，主要为上皮癌。与已知疾病模式相反，在我们中心，上皮性卵巢癌在多产妇女和50岁以下女性中更为常见。
