Department of Urology, Rush University Medical Center, Chicago, IL, USA.
J Sex Med. 2013 Dec;10(12):3121-8. doi: 10.1111/jsm.12334. Epub 2013 Oct 4.
Peyronie's disease (PD) is a connective tissue disorder of the penis in which a fibrous scar in the tunica albuginea can result in multiple penile deformities.
The study aims to investigate the prevalence and time to identification of plaque calcification (PC) in our PD patient population and whether stratification of calcification based on severity seen on ultrasound would serve as a predictor of treatment progression to surgery.
A retrospective review of 1,041 men presenting with PD from 1993 to 2009 was performed. Eight hundred thirty-four underwent penile duplex ultrasound.
PC was graded as: grade 1 (<0.3 cm), grade 2 (>0.3 cm, <1.5 cm), grade 3 (>1.5 cm; or ≥ 2 plaques >1.0 cm). A matched control group with noncalcified plaques (n = 236) was selected for comparison.
Two hundred eighty-four men (34%) were found to have PC noted on ultrasound, and 98 had fully documented dimensions of the PC. Forty-one percent were found to have grade 1, 28% grade 2, and 32% grade 3. When analyzed by grade and progression to surgery, 23% of grade 1, 32% of grade 2, and 55% of grade 3 patients had surgery. Those with grade 3 PC were more likely to undergo surgical intervention for PD (OR 2.28 95% CI 1.07-4.86) and more likely to undergo a grafting procedure than control patients (P < 0.0001).
Men with PC are not more likely to undergo surgery than those without PC (OR 0.95, 95% CI 0.58-1.57). PC is not uncommon, as it was found in 34% of our cohort. PC does not appear to be an indication of mature or stable disease, as it was identified by ultrasound in 37% of patients less than 12 months after onset of symptoms. Men with grade 3 PC have an increased likelihood of progression to surgical intervention and a higher likelihood of undergoing a grafting procedure.
佩罗尼氏病（PD）是一种阴茎结缔组织疾病，其中白膜中的纤维疤痕可导致多种阴茎畸形。
本研究旨在调查我们 PD 患者人群中斑块钙化（PC）的患病率和识别时间，以及根据超声所见严重程度对钙化进行分层是否可作为预测治疗进展为手术的指标。
回顾性分析了 1993 年至 2009 年期间就诊的 1041 名 PD 男性患者。834 名患者接受了阴茎双功能超声检查。
PC 分级为：1 级（<0.3cm），2 级（>0.3cm，<1.5cm），3 级（>1.5cm；或≥2 个斑块>1.0cm）。选择了 236 名无钙化斑块的匹配对照组进行比较。
284 名男性（34%）在超声检查中发现有 PC，98 名男性的 PC 有完整的记录尺寸。41%为 1 级，28%为 2 级，32%为 3 级。按等级和手术进展进行分析，1 级中有 23%、2 级中有 32%、3 级中有 55%的患者进行了手术。3 级 PC 患者更有可能接受 PD 手术治疗（OR 2.28，95%CI 1.07-4.86），并且比对照组患者更有可能接受移植物手术（P<0.0001）。
有 PC 的男性比无 PC 的男性更有可能接受手术（OR 0.95，95%CI 0.58-1.57）。PC 并不少见，在我们的队列中发现了 34%。PC 似乎不是疾病成熟或稳定的指标，因为在症状出现后不到 12 个月，37%的患者通过超声检查发现了 PC。3 级 PC 患者更有可能进展为手术干预，并且更有可能接受移植物手术。
