Nilsson L, Kogure K, Busto R
Acta Anaesthesiol Scand. 1975;19(3):199-205. doi: 10.1111/j.1399-6576.1975.tb05241.x.
The influence of elevated and reduced body temperatures upon the metabolic state of the brain was evaluated from the tissue concentrations of phosphocreatine (PCr) ATP, ADP and AMP and from the concentrations of glucose, lactate and pyruvate in immobilized and artificially ventilated rats anesthetized with 70% N2O. The results were compared to the results obtained in normothermic animals. It was found that rats with body temperatures of 32 degrees and 22 degrees C had the same brain tissue concentrations of high energy phosphates and the same adenylate energy charge as the controls, but hypothermia led to a progressive decrease of both cerebral and arterial lactate and pyruvate concentrations. A metabolic acidosis but no excess lactate appeared in the blood. At a body temperature of 42 degrees C, the metabolic pattern in the brain agreed with a state of hypoxia at a time when there was no sign of substrate depletion. Arterial blood showed excess lactate which may indicate an inadequacy of the oxygen supply also to other tissues.
通过测定用70%氧化亚氮麻醉、固定并人工通气的大鼠脑组织中磷酸肌酸（PCr）、三磷酸腺苷（ATP）、二磷酸腺苷（ADP）和一磷酸腺苷（AMP）的浓度，以及葡萄糖、乳酸和丙酮酸的浓度，评估体温升高和降低对脑代谢状态的影响。将结果与正常体温动物的结果进行比较。发现体温为32摄氏度和22摄氏度的大鼠脑组织中高能磷酸盐的浓度和腺苷酸能荷与对照组相同，但体温过低导致脑和动脉中乳酸和丙酮酸浓度逐渐降低。血液中出现代谢性酸中毒但没有过量乳酸。在体温为42摄氏度时，大脑中的代谢模式与缺氧状态一致，此时没有底物耗竭的迹象。动脉血中乳酸过量，这可能表明其他组织的氧气供应也不足。
