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经皮微创锁定加压钢板内固定联合富血小板血浆治疗青壮年患者肱骨干骨折不愈合

A new way to treat forearm post-traumatic non-union in young patients with intramedullary nailing and platelet-rich plasma.

机构信息

Unità Operativa Complessa di Ortopedia e Traumatologia Pediatrica, Istituto Ortopedico G. Pini, Milan, Italy.

II Division, Istituto CTO, Milan, Italy.

出版信息

Injury. 2014 Feb;45(2):418-23. doi: 10.1016/j.injury.2013.09.021. Epub 2013 Sep 20.

Abstract

INTRODUCTION

Non-union rate in forearm fractures is generally less than 2% when a proper technique is used; this rate increases when ulnar lesions are involved.

PATIENTS AND METHODS

We present a case series of seven young patients whose average age was 14 years (range 11-19 years) at the time of surgery and who presented with a forearm post-traumatic non-union that was previously treated in different ways (three isolated ulnar non-union, two isolated radial non-union and two combined). Average follow-up was 34 months (range 9-72 months). Surgical treatment began with the removal of the previous synthesis and with curettage of the non-union area. The Acumed ulnar rod, Acumed radial rod and Thalon elastic nail (all of them are unreamed and locked nails) together with autologous platelet-rich plasma (PRP) obtained with the Biomet System (concentration of 158.2×10(4) platelets/μL) were chosen to treat the patients. X-rays and clinical controls were conducted every 30 days until recovery.

RESULTS

All patients recovered: average recovery was 23 weeks from operation (range 16-36 weeks) and nails were removed 3 months after complete healing. Six patients had excellent results and one patient had a good result (Patient 2, forearm pronosupination 60-0-40 degrees).

DISCUSSION

The purpose of the case series was to establish a better way of treatment and to find a technique that could avoid the use of bone grafts, because obtaining autologous bone requires a further surgical procedure that can be really invasive depending on the amount of bone needed.

CONCLUSION

All patients in the study showed complete recovery, with excellent clinical outcomes. Although there were only seven patients in this case series, and there is a need to analyse more patients, this study showed that the use of a specific locking nail system can provide proper stability to ulnar or radial atrophic non-union despite rotational forces, and when combined with autologous growth factors (PRP) is sufficient to promote bone healing in young patients without the necessity to take autologous bone grafts.

摘要

简介

在正确的技术下,前臂骨折的不愈合率一般小于 2%;当涉及到尺骨病变时,这个比率会增加。

患者和方法

我们报告了 7 例年轻患者的病例系列,他们在手术时的平均年龄为 14 岁(范围为 11-19 岁),并以前接受过不同方式治疗的前臂创伤后不愈合(3 例单纯尺骨不愈合,2 例单纯桡骨不愈合,2 例合并)。平均随访时间为 34 个月(范围 9-72 个月)。手术治疗开始时,去除先前的合成物,并刮除不愈合区域。选用 Acumed 尺骨杆、Acumed 桡骨杆和 Thalon 弹性钉(均为非扩髓锁定钉)以及 Biomet 系统获得的自体富血小板血浆(PRP)(浓度为 158.2×10(4) 个血小板/μL)来治疗患者。每 30 天进行一次 X 射线和临床检查,直到恢复。

结果

所有患者均康复:从手术到恢复的平均时间为 23 周(范围 16-36 周),完全愈合后 3 个月取出钉。6 例患者结果优秀,1 例患者结果良好(患者 2,前臂旋前/旋后 60-0-40 度)。

讨论

病例系列的目的是建立一种更好的治疗方法,并找到一种可以避免使用骨移植物的技术,因为获得自体骨需要进一步的手术,这可能会根据需要的骨量而非常侵入性。

结论

研究中的所有患者均完全康复,临床结果良好。尽管本病例系列仅包括 7 例患者,并且需要分析更多的患者,但本研究表明,使用特定的锁定钉系统可以在桡骨或尺骨萎缩性不愈合时提供适当的稳定性,尽管存在旋转力,并且当与自体生长因子(PRP)结合时,可以为年轻患者促进骨愈合,而无需进行自体骨移植。

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