Han Jun-qing, Liu Qi, Sun Cheng-tao, Yao Jian, Zhao Bin, Wang Hong
The Center of Tumor Research and Therapy, Shandong Provincial Hospital affiliated to Shandong University, Jinan 250021, China (Email:
Zhonghua Zhong Liu Za Zhi. 2013 Jun;35(6):468-71.
To investigate the clinical efficacy and safety of low-frequency rotary magnetic fields in the treatment of patients with advanced malignant tumors.
137 patients with advanced malignant tumors were exposed to 400 r/min, 0.4 T low-frequency rotary magnetic fields. An area including the primary tumor, local metastasis and metastatic lymph nodes was exposed daily, 2 hours per day for 30~50 days (average time of 42 days).
All of the 137 patients completed the low-frequency rotary magnetic field treatment. There were 28 cases with complete response, 54 cases with partial response, and the clinical benefit rate was 59.9%. The tumor type, initial KPS and QOL showed statistical significance in the clinical benefit rate (P < 0.05). The median overall survival was 12 months, and the 1-year, 2-year and 3-year survival rates were 47.0%, 11.8%, 3.4%, respectively. The tumor type, initial KPS and QOL were identified by univariate log-rank test as significant prognostic factors for overall survival (P < 0.05). Multivariate analysis showed that the initial QOL was an independent prognostic factors (P = 0.037) . During the treatment, asthenia and local pain were observed in 11 patients, and 6 patients had mild tachycardia (increased 3 to 5/min) and/or temperature elevation (0.5 to 1.0°C). All above symptoms disappeared spontaneously. No treatment-related death was observed.
Low-frequency rotary magnetic fields is an effective and safe method in the treatment of patients with advanced malignant tumors, and may prolong survival significantly.
探讨低频旋转磁场治疗晚期恶性肿瘤患者的临床疗效及安全性。
137例晚期恶性肿瘤患者接受400转/分钟、0.4特斯拉的低频旋转磁场治疗。每日对包括原发肿瘤、局部转移灶及转移淋巴结在内的区域进行照射，每天2小时，共30~50天（平均42天）。
137例患者均完成低频旋转磁场治疗。完全缓解28例，部分缓解54例，临床获益率为59.9%。肿瘤类型、初始KPS及QOL在临床获益率方面显示出统计学意义（P<0.05）。中位总生存期为12个月，1年、2年和3年生存率分别为47.0%、11.8%、3.4%。单因素对数秩检验确定肿瘤类型、初始KPS及QOL为总生存期的显著预后因素（P<0.05）。多因素分析显示初始QOL为独立预后因素（P = 0.037）。治疗期间，11例患者出现乏力和局部疼痛，6例患者出现轻度心动过速（每分钟增加3至5次）和/或体温升高（0.5至1.0°C）。上述所有症状均自行消失。未观察到与治疗相关的死亡。
低频旋转磁场是治疗晚期恶性肿瘤患者的一种有效且安全的方法，可能显著延长生存期。
