Zhang Xing-ru, Liu Ye-xiang, Sheng Xia, Zhou Huan-ming, Han Zhu-mei, Fu Zhi-xuan, Li Qing-song, Xiang Min-hong
Department of Ophthalmology, Putuo Hospital Affiliated to Shanghai University of Traditional Medicine, Shanghai 200062, China (Email:
Zhonghua Yan Ke Za Zhi. 2013 Jun;49(6):547-50.
To investigate the relationship between the occurrence and development of conjunctivochalasis and bulbar conjunctival lymphangiectasia.
Case control study. One hundred cases with conjunctivochalasis treated from January to March 2012 were selected to study, and 100 cases with no conjunctivochalasis as the control group at the same time. To observe bulbar conjunctiva lymphatic duct dilatation using slit lamp microscope, analysis bulbar conjunctiva and fascia images by OCT scanning, and ablate lymphatic of conjunctival tissue for pathologic examine.
Twenty-nine eyes of the bulbar conjunctiva lymphangiectasia associated with 100 cases (183 eyes) conjunctivochalasis patients, accounting for 15.84%; 8 eyes of the ball conjunctival lymphatic dilation in control group of 100 cases ( 200 eyes), accounting for 4.00%. The difference between the two groups was statistically significant (χ(2) = 15.36, P < 0.001). OCT scanning showed that lymphangiectasia of the conjunctiva is at the subcutaneous mainly, some in the conjunctival lamina propria. They are border-clear, full-filled fluid, single-lumen or multi lumens, not involving the fascia. The histopathological examination showed that the lamina propria of the bulbar conjunctiva mildly chronic inflammatory changes accompanied by a large number of lymphangiectasia.
Bulbar conjunctival lymphangiectasia may be one of the reasons for the conjunctivochalasis.
探讨结膜松弛症的发生发展与球结膜淋巴管扩张之间的关系。
病例对照研究。选取2012年1月至3月治疗的100例结膜松弛症患者进行研究，同时选取100例无结膜松弛症患者作为对照组。使用裂隙灯显微镜观察球结膜淋巴管扩张情况，通过OCT扫描分析球结膜及筋膜图像，并对结膜组织淋巴管进行切除以做病理检查。
100例（183只眼）结膜松弛症患者中29只眼球结膜淋巴管扩张，占15.84%；100例（200只眼）对照组中8只眼球结膜淋巴管扩张，占4.00%。两组差异有统计学意义（χ(2)=15.36，P<0.001）。OCT扫描显示，结膜淋巴管扩张主要位于皮下，部分位于结膜固有层。边界清晰，充满液体，单腔或多腔，未累及筋膜。组织病理学检查显示，球结膜固有层有轻度慢性炎症改变并伴有大量淋巴管扩张。
球结膜淋巴管扩张可能是结膜松弛症的原因之一。
