Gan Jing-Yun, Li Qing-Song, Zhang Zhen-Yong, Zhang Wei, Zhang Xing-Ru
Department of Ophthalmology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, China.
Int J Ophthalmol. 2017 Sep 18;10(9):1465-1473. doi: 10.18240/ijo.2017.09.21. eCollection 2017.
The PubMed, MEDLINE databases and China National Knowledge Infrastructure (CNKI) were searched for information regarding the etiology and pathogenesis of conjunctivochalasis (CCh) and the synthesis and degradation of elastic fibers. After analysis of the literature, we found elastic fibers was a complex protein molecule from the structure and composition; the degradation of elastic fibers was one of the histopathological features of the disease; the vast majority of the factors related to the pathogenesis of CCh ultimately pointed to abnormal elastic fibers. By reasonably speculating, we considered that abnormal elastic fibers cause the conjunctival relaxation. In conclusion, we hypothesize that elastic fibers play an important role in the pathogenesis of CCh. Studies on the mechanism of synthesis, degradation of elastic fibers are helpful to clarify the pathogenesis of the disease and to find effective treatment methods.
我们检索了PubMed、MEDLINE数据库以及中国知网（CNKI），以获取有关结膜松弛症（CCh）的病因和发病机制以及弹性纤维合成与降解的信息。通过对文献的分析，我们发现弹性纤维从结构和组成来看是一种复杂的蛋白质分子；弹性纤维的降解是该疾病的组织病理学特征之一；绝大多数与CCh发病机制相关的因素最终都指向弹性纤维异常。通过合理推测，我们认为弹性纤维异常导致结膜松弛。总之，我们推测弹性纤维在CCh的发病机制中起重要作用。对弹性纤维合成、降解机制的研究有助于阐明该疾病的发病机制并找到有效的治疗方法。
