Nanomedicine Research Center, Department of Neurosurgery at Cedars-Sinai Medical Center, Los Angeles, CA, United States.
Adv Drug Deliv Rev. 2013 Nov;65(13-14):1866-79. doi: 10.1016/j.addr.2013.09.019. Epub 2013 Oct 10.
Nanomedicine is an emerging form of therapy that focuses on alternative drug delivery and improvement of the treatment efficacy while reducing detrimental side effects to normal tissues. Cancer drug resistance is a complicated process that involves multiple mechanisms. Here we discuss the major forms of drug resistance and the new possibilities that nanomedicines offer to overcome these treatment obstacles. Novel nanomedicines that have a high ability for flexible, fast drug design and production based on tumor genetic profiles can be created making drug selection for personal patient treatment much more intensive and effective. This review aims to demonstrate the advantage of the young medical science field, nanomedicine, for overcoming cancer drug resistance. With the advanced design and alternative mechanisms of drug delivery known for different nanodrugs including liposomes, polymer conjugates, micelles, dendrimers, carbon-based, and metallic nanoparticles, overcoming various forms of multi-drug resistance looks promising and opens new horizons for cancer treatment.
纳米医学是一种新兴的治疗形式，专注于替代药物输送，并提高治疗效果，同时减少对正常组织的有害副作用。癌症药物耐药性是一个复杂的过程，涉及多种机制。在这里，我们讨论了主要的耐药形式以及纳米医学提供的克服这些治疗障碍的新可能性。新型纳米药物具有基于肿瘤遗传特征灵活、快速药物设计和生产的高能力，可以创造出针对个体患者治疗的更密集和有效的药物选择。本综述旨在展示年轻的医学科学领域——纳米医学在克服癌症药物耐药性方面的优势。通过先进的设计和不同纳米药物（包括脂质体、聚合物缀合物、胶束、树枝状大分子、基于碳的和金属纳米颗粒）已知的替代药物输送机制，克服各种形式的多药耐药性看起来很有希望，并为癌症治疗开辟了新的前景。
