Veterinary Faculty, College of Veterinary Medicine, Hunan Agricultural University, Changsha, China.
Cell Biochem Funct. 2014 Apr;32(3):258-67. doi: 10.1002/cbf.3009. Epub 2013 Oct 3.
Pancreatic cancer (PC) has a high rate of mortality and a poorly understood mechanism of progression. Investigation of the molecular mechanism of PC and exploration of the specific markers for early diagnosis and specific targets of therapy are key points to prevent and treat PC effectively and to improve their prognosis. In our study, expression profiles experiment of para-carcinoma, carcinoma and relapse human PC was performed using Agilent human whole genomic oligonucleotide microarrays with 45 000 probes. Differentially expressed genes related with PC were screened and analysed further by Gene Ontology term analysis and Kyoto encyclopaedia of genes and genomes pathway analysis. Our results showed that there were 3853 differentially expressed genes associated with pancreatic carcinogenesis and relapse. In addition, our study found that PC was related to the Jak-STAT signalling pathway, PPAR signalling pathway and Calcium signalling pathway, indicating their potential roles in pancreatic carcinogenesis and progress.
胰腺癌（PC）的死亡率很高，其进展机制也未被充分理解。研究 PC 的分子机制，探索用于早期诊断的特异性标志物和治疗的特异性靶点，是有效预防和治疗 PC 并改善其预后的关键点。在我们的研究中，使用 Agilent 人类全基因组寡核苷酸微阵列对癌旁、癌组织和复发的人 PC 进行了表达谱实验，该微阵列包含 45000 个探针。通过基因本体论术语分析和京都基因与基因组百科全书通路分析，进一步筛选和分析与 PC 相关的差异表达基因。我们的结果表明，有 3853 个与胰腺癌发生和复发相关的差异表达基因。此外，我们的研究还发现，PC 与 Jak-STAT 信号通路、PPAR 信号通路和钙信号通路有关，这表明它们在胰腺癌的发生和进展中可能具有重要作用。
