He Chengzhi, Jiang Hua, Geng Shasha, Sheng Haihui, Shen Xiaoying, Zhang Xiaoyan, Zhu Shizhang, Chen Ximei, Yang Changqing, Gao Hengjun
Department of Gastroenterology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, China.
Int J Clin Exp Pathol. 2012;5(6):537-46. Epub 2012 Jul 29.
The tumorigenesis of pancreatic cancer is thought to be a complex process. Investigation of the molecular mechanism of pancreatic cancer and exploring the specific markers for early diagnosis and specific targets of therapy is a key point to prevent and treat pancreatic cancer effectively and to improve their prognosis. In this study, expression profiles experiment was performed using Agilent human whole genomic oligonucleotide microarrays with 41,000 genes. Differentially expressed genes related with pancreatic cancer were screened, and analyzed further by GO term analysis and KEGG Pathway analysis. Our results showed that there were 1276 differentially expressed genes associated with pancreatic cancer. 691 genes were up regulated and 585 were down regulated in pancreatic cancer group. The present study confirmed that the occurrence of pancreatic cancer was involved in multiple-gene interaction. In addition, our study found that pancreatic cancer was related to an activation of the mTOR signaling pathway and renal cell carcinoma pathway.
胰腺癌的肿瘤发生被认为是一个复杂的过程。研究胰腺癌的分子机制并探索早期诊断的特异性标志物和治疗的特异性靶点，是有效预防和治疗胰腺癌并改善其预后的关键。在本研究中，使用具有41000个基因的安捷伦人类全基因组寡核苷酸微阵列进行表达谱实验。筛选出与胰腺癌相关的差异表达基因，并通过基因本体论（GO）分析和京都基因与基因组百科全书（KEGG）通路分析进行进一步分析。我们的结果表明，有1276个与胰腺癌相关的差异表达基因。在胰腺癌组中，691个基因上调，585个基因下调。本研究证实胰腺癌的发生涉及多基因相互作用。此外，我们的研究发现胰腺癌与mTOR信号通路和肾细胞癌通路的激活有关。
