伯纳特柯克斯体在免疫抑制小鼠体内从II期到I期的转变
Phase II to phase I conversion of Coxiella burneti in immunosuppressed mice.
作者信息
Kazár J, Brezina R, Skultétyová E, Kovácová E, Schramek S
出版信息
Acta Virol. 1975 Jul;19(4):359-63.
PMID:241236
Abstract
Coxiella burneti strains 48 and Nine Mile, serologically in phase II, changed their antigenic properties and virulence for guinea pigs and mice upon passaging in immunosuppressed mice. Conversion to phase I of these strains in a system lacking antibody response throws doubt on the importance of specific antibodies in phase variation of C. burneti.
摘要
柯克斯体菌株48和九里株，血清学上处于II相，在免疫抑制小鼠中传代后，其抗原特性以及对豚鼠和小鼠的毒力发生了改变。在缺乏抗体应答的系统中，这些菌株转变为I相，这使人对特异性抗体在伯氏柯克斯体相变中的重要性产生怀疑。
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