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本文引用的文献

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Engineered Streptomyces avermitilis host for heterologous expression of biosynthetic gene cluster for secondary metabolites.用于次生代谢物生物合成基因簇异源表达的工程阿维链霉菌宿主。
ACS Synth Biol. 2013 Jul 19;2(7):384-96. doi: 10.1021/sb3001003. Epub 2013 Jan 17.
2
Molecular regulation of antibiotic biosynthesis in streptomyces.链霉菌中抗生素生物合成的分子调控。
Microbiol Mol Biol Rev. 2013 Mar;77(1):112-43. doi: 10.1128/MMBR.00054-12.
3
Signals and regulators that govern Streptomyces development.调控链霉菌发育的信号和调控因子。
FEMS Microbiol Rev. 2012 Jan;36(1):206-31. doi: 10.1111/j.1574-6976.2011.00317.x. Epub 2011 Dec 2.
4
Streptomyces coelicolor sRNA scr5239 inhibits agarase expression by direct base pairing to the dagA coding region.变铅青链霉菌 sRNA scr5239 通过与 dagA 编码区直接碱基配对抑制琼脂酶表达。
Microbiology (Reading). 2012 Feb;158(Pt 2):424-435. doi: 10.1099/mic.0.054205-0. Epub 2011 Nov 10.
5
Regulation by small RNAs in bacteria: expanding frontiers.细菌中小 RNA 的调控：拓展前沿。
Mol Cell. 2011 Sep 16;43(6):880-91. doi: 10.1016/j.molcel.2011.08.022.
6
The autoregulator receptor homologue AvaR3 plays a regulatory role in antibiotic production, mycelial aggregation and colony development of Streptomyces avermitilis.自调节受体同源物 AvaR3 在阿维链霉菌抗生素产生、菌丝聚集和菌落发育中发挥调节作用。
Microbiology (Reading). 2011 Aug;157(Pt 8):2266-2275. doi: 10.1099/mic.0.048371-0. Epub 2011 May 26.
7
Deep sequencing-based identification of small non-coding RNAs in Streptomyces coelicolor.基于深度测序的链霉菌中微小非编码 RNA 的鉴定。
RNA Biol. 2011 May-Jun;8(3):468-77. doi: 10.4161/rna.8.3.14421. Epub 2011 May 1.
8
Genome-wide inference of regulatory networks in Streptomyces coelicolor.全基因组推断链霉菌调控网络。
BMC Genomics. 2010 Oct 18;11:578. doi: 10.1186/1471-2164-11-578.
9
Quantitative proteomics analysis of Streptomyces coelicolor development demonstrates that onset of secondary metabolism coincides with hypha differentiation.链霉菌发育的定量蛋白质组学分析表明，次级代谢的开始与菌丝分化同时发生。
Mol Cell Proteomics. 2010 Jul;9(7):1423-36. doi: 10.1074/mcp.M900449-MCP200. Epub 2010 Mar 11.
10
Putative TetR family transcriptional regulator SCO1712 encodes an antibiotic downregulator in Streptomyces coelicolor.推测的 TetR 家族转录调节因子 SCO1712 在链霉菌中编码一种抗生素下调因子。
Appl Environ Microbiol. 2010 May;76(9):3039-43. doi: 10.1128/AEM.02426-09. Epub 2010 Feb 26.

SdrA，一种参与阿维链霉菌形态发育和抗生素生产的新型DeoR家族调控因子。

SdrA, a new DeoR family regulator involved in Streptomyces avermitilis morphological development and antibiotic production.

作者信息

Ulanova Dana, Kitani Shigeru, Fukusaki Eiichiro, Nihira Takuya

机构信息

International Center for Biotechnology, Osaka University, Osaka, Japan.

出版信息

Appl Environ Microbiol. 2013 Dec;79(24):7916-21. doi: 10.1128/AEM.02843-13. Epub 2013 Oct 11.

DOI:10.1128/AEM.02843-13
PMID:24123736
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3837817/
Abstract

The SAV3339 (SdrA) protein of Streptomyces avermitilis, a member of the DeoR family of regulators, was assessed to determine its in vivo function by gene knockdown through the use of cis-encoded noncoding RNA and knockout of the sdrA gene. These analyses revealed that SdrA represents another class of Streptomyces regulator that controls morphological development and antibiotic production.

摘要

阿维链霉菌的SAV3339（SdrA）蛋白是DeoR家族调控因子的成员之一，通过使用顺式编码的非编码RNA进行基因敲低和敲除sdrA基因来评估其体内功能。这些分析表明，SdrA代表了另一类控制形态发育和抗生素产生的链霉菌调控因子。