SdrA，一种参与阿维链霉菌形态发育和抗生素生产的新型DeoR家族调控因子。
SdrA, a new DeoR family regulator involved in Streptomyces avermitilis morphological development and antibiotic production.
作者信息
Ulanova Dana, Kitani Shigeru, Fukusaki Eiichiro, Nihira Takuya
机构信息
International Center for Biotechnology, Osaka University, Osaka, Japan.
出版信息
Appl Environ Microbiol. 2013 Dec;79(24):7916-21. doi: 10.1128/AEM.02843-13. Epub 2013 Oct 11.
Abstract
The SAV3339 (SdrA) protein of Streptomyces avermitilis, a member of the DeoR family of regulators, was assessed to determine its in vivo function by gene knockdown through the use of cis-encoded noncoding RNA and knockout of the sdrA gene. These analyses revealed that SdrA represents another class of Streptomyces regulator that controls morphological development and antibiotic production.
摘要
阿维链霉菌的SAV3339（SdrA）蛋白是DeoR家族调控因子的成员之一，通过使用顺式编码的非编码RNA进行基因敲低和敲除sdrA基因来评估其体内功能。这些分析表明，SdrA代表了另一类控制形态发育和抗生素产生的链霉菌调控因子。
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