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推测的 TetR 家族转录调节因子 SCO1712 在链霉菌中编码一种抗生素下调因子。

Putative TetR family transcriptional regulator SCO1712 encodes an antibiotic downregulator in Streptomyces coelicolor.

机构信息

Department of Biological Engineering, Inha University, Incheon, South Korea.

出版信息

Appl Environ Microbiol. 2010 May;76(9):3039-43. doi: 10.1128/AEM.02426-09. Epub 2010 Feb 26.

DOI:10.1128/AEM.02426-09
PMID:20190084
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2863465/
Abstract

A tetR family transcriptional regulatory gene (SCO1712) was identified as a global antibiotic regulatory gene from a Streptomyces interspecies DNA microarray analysis. SCO1712 disruption in Streptomyces coelicolor not only upregulated antibiotic biosynthesis through pathway-specific regulators when a previously identified pleiotropic downregulatory wblA was expressed but also further stimulated antibiotic production in a wblA deletion mutant, implying that SCO1712 might encode a novel antibiotic downregulator.

摘要

从链霉菌种间 DNA 微阵列分析中鉴定出 tetR 家族转录调控基因 (SCO1712) 作为一种全局抗生素调控基因。链霉菌中 SCO1712 的破坏不仅在上调抗生素生物合成途径特异性调控因子时通过先前鉴定的多效下调 wblA 表达，而且还进一步刺激 wblA 缺失突变体中的抗生素产生，这表明 SCO1712 可能编码一种新型抗生素下调因子。

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Proc Natl Acad Sci U S A. 2008 Aug 12;105(32):11346-51. doi: 10.1073/pnas.0803622105. Epub 2008 Aug 6.
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