Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne NE4 5PL, UK.
Age Ageing. 2014 Jan;43(1):57-63. doi: 10.1093/ageing/aft153. Epub 2013 Oct 11.
to examine the association between subjective and objective measures of sleep and wake and other health parameters in a cohort of the very old.
a population-based cohort study.
primary care, North East England.
four hundred and twenty-one men and women, aged 87-89, recruited to the Newcastle 85+ Study cohort.
sleep questionnaires were administered and sleep-wake patterns were assessed over 5-7 days with a novel wrist triaxial accelerometer. Associations between sleep measures and various health parameters, including mortality at 24 months, were examined.
only 16% of participants perceived their sleep as severely disturbed as assessed with questionnaire responses. Wrist accelerometry showed marked variation between normal and abnormal sleep-wake cycles that did not correlate with the participants' perception of sleep. Impaired sleep-wake cycles were significantly associated with cognitive impairment, disability, depression, increased falls, body mass index and arthritis but not with any other specific disease markers and with decreased survival.
commonly used sleep questionnaires do not differentiate well between those with objectively determined disturbance of sleep-wake cycles and those with normal cycles. Abnormal sleep-wake patterns are associated with institutionalisation, cognitive impairment, disability, depression and arthritis but not with other diseases; there is also an association with reduced survival.
在一个非常高龄的队列中，检查主观和客观睡眠及其他健康参数之间的关联。
基于人群的队列研究。
英格兰东北部的初级保健。
421 名年龄在 87-89 岁的男性和女性，招募自纽卡斯尔 85+研究队列。
进行睡眠问卷评估，并使用新型腕部三轴加速度计在 5-7 天内评估睡眠-觉醒模式。检查睡眠测量与各种健康参数之间的关联，包括 24 个月时的死亡率。
只有 16%的参与者认为他们的睡眠受到严重干扰，这是通过问卷回答评估的。腕部加速度计显示正常和异常睡眠-觉醒周期之间存在明显差异，但与参与者对睡眠的感知无关。睡眠-觉醒周期受损与认知障碍、残疾、抑郁、增加跌倒、体重指数和关节炎显著相关，但与其他特定疾病标志物无关，与生存率降低相关。
常用的睡眠问卷不能很好地区分那些客观上睡眠-觉醒周期紊乱的人和那些正常周期的人。异常的睡眠-觉醒模式与住院、认知障碍、残疾、抑郁和关节炎有关，但与其他疾病无关；与生存率降低也有关。
