The University of Texas MD Anderson Cancer Center, Dept of Hematopathology, Box 72, 1515 Holcombe Blvd, Houston, TX 77030; e-mail:
Am J Clin Pathol. 2013 Nov;140(5):693-700. doi: 10.1309/AJCPEMVXES72DUIF.
To describe the clinicopathologic findings of seven patients with CD5-positive nodal marginal zone lymphoma (NMZL).
We searched cases of NMZL over a 10-year interval and identified seven cases of CD5-positive NMZL. The clinical, histologic, and immunophenotypic findings of this group were reviewed, and the frequency of dissemination in this group was compared with that of 66 patients with CD5-negative NMZL.
Other than CD5 expression, the histologic and immunophenotypic findings were typical of NMZL. Six (86%) of seven patients had lymphadenopathy above and below the diaphragm, and all six patients assessed had bone marrow involvement. In the CD5-negative group, 28 (42%) patients had lymphadenopathy above and below the diaphragm, and 36 (55%) had bone marrow involvement (P = .045 and P = .037, respectively). Six of seven patients were alive at last follow-up, with a median follow-up of 32 months (3-154 months).
CD5 expression in NMZL correlates with a higher frequency of dissemination, but patients have an indolent clinical course and excellent overall survival.
描述 7 例 CD5 阳性结内边缘区淋巴瘤（NMZL）患者的临床病理特征。
我们在 10 年间检索了 NMZL 病例，并鉴定出 7 例 CD5 阳性 NMZL。回顾了该组患者的临床、组织学和免疫表型特征，并比较了该组的播散频率与 66 例 CD5 阴性 NMZL 患者的播散频率。
除了 CD5 表达之外，这些组织学和免疫表型特征均为 NMZL 的典型表现。7 例患者中的 6 例（86%）存在膈上下淋巴结病，且所有 6 例评估患者均存在骨髓受累。在 CD5 阴性组中，28 例（42%）患者存在膈上下淋巴结病，36 例（55%）患者存在骨髓受累（P=.045 和 P=.037）。在最后一次随访时，7 例患者中的 6 例存活，中位随访时间为 32 个月（3-154 个月）。
NMZL 中的 CD5 表达与更高的播散频率相关，但患者具有惰性的临床病程和极好的总体生存率。
