Gene Expression Analysis Laboratory, Cancer Research UK London Research Institute, London, United Kingdom.
Cancer Discov. 2013 Oct;3(10):1105-7. doi: 10.1158/2159-8290.CD-13-0565.
In a recent issue of Cancer Cell, Patra and colleagues report findings that underscore the importance of Hexokinase 2 (HK2) in tumor initiation and maintenance. The authors also show that HK2 can be systemically deleted without adverse physiologic consequences. These findings provide attractive insights into HK2 deletion as a potential therapeutic intervention for cancer.
在最近一期的《癌细胞》杂志上，Patra 及其同事报告了一些研究结果，这些结果强调了己糖激酶 2（Hexokinase 2，HK2）在肿瘤起始和维持中的重要性。作者还表明，系统删除 HK2 不会产生不良的生理后果。这些发现为 HK2 缺失作为癌症潜在治疗干预提供了有吸引力的见解。
