Terrin B N, Studer E J, Wood N, Mohanakumar T, Russell E C
Am J Hematol. 1985 Oct;20(2):175-81. doi: 10.1002/ajh.2830200211.
A case study is presented of a leukemic patient whose cells express markers of both myeloid and lymphoid cells. Cells were identified from bone marrow which expressed either myeloid antigens, lymphoid antigens, or both myeloid and lymphoid antigens, indicating a possible common stem cell capable of differentiating along either a lymphoid or myeloid cell lineage. Using specific monoclonal antibodies, 40-70% of the cells were reactive with anti-T-cell antibodies, 50% of the cells were reactive with antibodies to the common ALL antigen (CALLA), and 80-90% of the cells were reactive with antibodies directed against myeloid antigens. Using double staining techniques, some cells were found to demonstrate only myeloid markers; others, only lymphoid markers; and others, both myeloid and lymphoid markers. These results suggest that a common stem cell is capable of differentiating along both lymphoid and myeloid lineages.
本文呈现了一个白血病患者的病例研究，该患者的细胞表达髓系和淋巴系细胞的标志物。从骨髓中鉴定出的细胞表达髓系抗原、淋巴系抗原或同时表达髓系和淋巴系抗原，这表明可能存在一种能够沿淋巴系或髓系细胞谱系分化的共同干细胞。使用特异性单克隆抗体，40%-70%的细胞与抗T细胞抗体反应，50%的细胞与针对普通急性淋巴细胞白血病抗原（CALLA）的抗体反应，80%-90%的细胞与针对髓系抗原的抗体反应。使用双重染色技术，发现一些细胞仅显示髓系标志物；另一些仅显示淋巴系标志物；还有一些同时显示髓系和淋巴系标志物。这些结果表明，一种共同干细胞能够沿淋巴系和髓系谱系分化。
