Shimizu J, Hamashima Y, Tsuda H, Akiyama Y, Mikawa H, Ikehara S
Am J Hematol. 1987 Feb;24(2):199-205. doi: 10.1002/ajh.2830240211.
A 9-year-old boy suffering from T-cell acute lymphoblastic leukemia (T-ALL) with a mediastinal mass had a complete remission as a result of treatment. Ten months later, he developed a typical acute myelomonocytic leukemia (AMMoL) pattern. Two months after a second relapse, he showed a clinical picture that was indistinguishable from chronic myelocytic leukemia (CML). At autopsy, massive infiltration of CML-like cells was observed even in the thymus (190 g). These observations suggest that the leukemia in this child arose in a pluripotent stem cell capable of differentiation into both T-lymphocytic and myelomonocytic lineages.
一名患有T细胞急性淋巴细胞白血病（T-ALL）并伴有纵隔肿块的9岁男孩经治疗后完全缓解。10个月后，他发展为典型的急性粒单核细胞白血病（AMMoL）模式。第二次复发两个月后，他表现出与慢性粒细胞白血病（CML）难以区分的临床症状。尸检时，即使在胸腺（190克）中也观察到大量CML样细胞浸润。这些观察结果表明，该患儿的白血病起源于一种能够分化为T淋巴细胞和粒单核细胞谱系的多能干细胞。
