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人类血型多态性与甲型流感/香港(H3N2)的发病率

Polymorphism of human blood groups and incidence of influenza A/Hong Kong (H3N2).

作者信息

Frolov V K, Sokhin A A, Sotnik A Y, Frolov A K, Lebedinsky A P, Potapova N A, Lapina L M

出版信息

Acta Virol. 1975 Sep;19(5):406-12.

PMID:241245
Abstract

During three epidemics of influenza A/Hong Kong (H3N2) and experimentally in vaccines, the relation between influenza infection and ABo, Rh and MN blood groups was studied. Examinations of 2760 patients with laboratory-confirmed diagnosis of influenza and 749 persons vaccinated with live influenza vaccine showed that individuals of blood groups O and B were susceptible to influenza 1.67 and 1.20 times more, respectively, than individuals of blood group A. The difference in incidence was most manifested in first attacks and decreased in subsequent epidemics. The increased incidence in individuals of blood groups O and B as compared to those of blood group A was not associated with factors of specific (antibody) and nonspecific (interferon) resistance to influenza but was related to a greater capacity of leukocytes from these individuals to adsorb the virus. No relation between blood groups Ph and MN and incidence of influenza A/Hong Kong (H3N2) was established.

摘要

在三次甲型香港流感(H3N2)流行期间以及在疫苗实验中,研究了流感感染与ABO、Rh和MN血型之间的关系。对2760例实验室确诊的流感患者和749例接种了流感活疫苗的人进行检查后发现,O型血和B型血的个体感染流感的易感性分别比A型血的个体高1.67倍和1.20倍。发病率的差异在首次发病时最为明显,在随后的流行中有所下降。与A型血个体相比,O型血和B型血个体发病率的增加与对流感的特异性(抗体)和非特异性(干扰素)抵抗力因素无关,而是与这些个体的白细胞吸附病毒的能力更强有关。未发现Ph血型和MN血型与甲型香港流感(H3N2)发病率之间存在关联。

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