Department of Medico-Surgical Sciences and Biotechnologies, Urology Unit, ICOT Latina, Sapienza University of Rome, Latina, Italy.
BMC Gastroenterol. 2013 Oct 14;13:149. doi: 10.1186/1471-230X-13-149.
Metastatic penile carcinoma derived from cholangiocarcinoma (CCA) has not been previously reported in the literature. Common metastatic sites for CCA include the regional lymph nodes and adjacent organs. CCAs are not highly vascularised tumours, making hematogenous metastases uncommon. Hematogenous CCA metastases commonly occur at distant organs such as the lungs, adrenal glands, and bones. Median survival for patients with metastatic disease is generally less than 1 year.
A 74-year-old Caucasian man consulted us after having undergone penile ultrasonography for pain and increased thickness at the base of the penis after self-examination. The patient presented with a history of hepatitis C-related cirrhosis and intrahepatic CCA, diagnosed 3 years previously. A biopsy of the corpora cavernosa on both sides revealed a carcinoma harbouring the same histological and immunophenotypical features as the primary hepatic lesion.
To date, there is no case of penile or urogenital system metastasis from CCA described in the literature. Therefore, this article represents the first case report of penile metastasis from CCA.
来源于胆管癌（CCA）的转移性阴茎癌在文献中尚未有报道。CCA 的常见转移部位包括局部淋巴结和邻近器官。CCA 不是高度血管化的肿瘤，因此血行转移并不常见。CCA 的血行转移通常发生在远处器官，如肺、肾上腺和骨骼。转移性疾病患者的中位生存期通常不到 1 年。
一名 74 岁的白人男性因自行检查时发现阴茎根部疼痛和增厚而行阴茎超声检查后前来就诊。该患者有丙型肝炎相关肝硬化和肝内 CCA 的病史，3 年前确诊。对双侧海绵体的活检显示存在一种癌，其具有与原发性肝病变相同的组织学和免疫表型特征。
迄今为止，文献中尚无 CCA 引起的阴茎或泌尿生殖系统转移的病例报道。因此，本文代表了首例 CCA 阴茎转移的病例报告。
