Chindaprasirt Jarin, Sookprasert Aumkhae, Sawanyawisuth Kittisak, Limpawattana Panita, Tiamkao Somsak
Medical Oncology Division, Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Asian Pac J Cancer Prev. 2012;13(5):1995-7. doi: 10.7314/apjcp.2012.13.5.1995.
Brain metastasis from cholangiocarcinoma (CCA) is a rare but fatal event. To the best of our knowledge, only few cases have been reported. Herein, we report the incident rate and a first case series of brain metastases from CCA.
Between January 2006 and December 2010 5,164 patients were treated at Srinagarind hospital, Khon Kaen University; of those, 8 patients developed brain metastasis. Here we reviewed clinical data and survival times.
The incident rate of brain metastases from CCA was 0.15%. The median age of the patients was 60 years. Tumor subtypes were intrahepatic in 6 and hilar in 2 patients. All suffered from symptoms related to brain metastasis. Three patients were treated with whole-brain radiation therapy (WBRT), one of whom also underwent surgery. The median survival after the diagnosis of brain metastasis was 9.5 weeks (1-28 weeks). The longest survival observed in a patient in RPA class I with two brain lesions and received WBRT.
This is a first case series of brain metastases from CCA with the incident rate of 0.15%. It is rare and associated with short survival time.
胆管癌（CCA）脑转移是一种罕见但致命的事件。据我们所知，仅有少数病例被报道。在此，我们报告CCA脑转移的发生率及首个病例系列。
2006年1月至2010年12月期间，孔敬大学诗里拉吉医院治疗了5164例患者；其中，8例发生了脑转移。在此我们回顾了临床资料和生存时间。
CCA脑转移的发生率为0.15%。患者的中位年龄为60岁。肿瘤亚型为肝内型6例，肝门型2例。所有患者均有与脑转移相关的症状。3例患者接受了全脑放射治疗（WBRT），其中1例还接受了手术。脑转移诊断后的中位生存期为9.5周（1 - 28周）。在RPA I级有两个脑转移灶并接受WBRT的患者中观察到最长生存期。
这是首个CCA脑转移病例系列，发生率为0.15%。它很罕见且生存期短。
