Brill' G E
Nauchnye Doki Vyss Shkoly Biol Nauki. 1985(7):23-6.
The mechanism of ADP and staphylococcal toxin effect on the platelet aggregation has been studied on the rabbit's platelet-rich plasma. Ca2+-channels blockade of the cell membrane by verapamil resulted in considerable inhibition of aggregation induced by ADP and some weakening of toxin action. Binding of extracellular calcium EDTA inhibited sharply or blocked the aggregation of both inductors. It has been concluded that Ca2+ transport into cell is necessary chain in ADP and staphylococcal toxin effect but under the action of toxin transport Ca2+ into platelet is brought through a verapamil-resistant Ca2+-channels forming in the membrane under the interaction with toxin.
在兔富血小板血浆上研究了二磷酸腺苷（ADP）和葡萄球菌毒素对血小板聚集的作用机制。维拉帕米对细胞膜钙通道的阻滞导致ADP诱导的聚集受到显著抑制，且毒素作用略有减弱。细胞外钙螯合剂乙二胺四乙酸（EDTA）的结合会急剧抑制或阻断两种诱导剂的聚集。得出的结论是，钙离子进入细胞是ADP和葡萄球菌毒素发挥作用的必要环节，但在毒素作用下，钙离子进入血小板是通过与毒素相互作用在膜上形成的对维拉帕米耐药的钙通道进行的。
