[Dependence of blood platelet aggregation capacity on agents affecting the intrathrombocyte Ca2+ content].

The effect of agents changing absorption and redistribution of Ca2+ in platelets on platelet aggregation was studied. It was shown that inhibition of intercellular Ca2+ absorption by verapamil and tetracain block of intracellular Ca2+ redistribution decrease platelet aggregation. A joint action of verapamil and tetracain increase the inhibition of aggregation. EDTA decreases platelet aggregation affecting platelet regulatory mechanisms associated with the action of cAMP and probably directed at a decrease in the platelet cytoplasmic Ca2+ content.