（18）F-FDG和（18）F-FDOPA PET/CT检查中患者剂量的估算。

Estimation of patient dose in (18)F-FDG and (18)F-FDOPA PET/CT examinations.

作者信息

Kaushik Aruna, Jaimini Abhinav, Tripathi Madhavi, D'Souza Maria, Sharma Rajnish, Mishra Anil K, Mondal Anupam, Dwarakanath Bilikere S

机构信息

Department of Radiation Biosciences, Institute of Nuclear Medicine and Allied Sciences, Brig. S.K. Mazumdar Road, Timarpur, Delhi, India.

出版信息

J Cancer Res Ther. 2013 Jul-Sep;9(3):477-83. doi: 10.4103/0973-1482.119354.

DOI:10.4103/0973-1482.119354

PMID:24125986

Abstract

PURPOSE

To estimate specific organ and effective doses to patients resulting from the (18)F-FDG ((18)F-2-deoxy-D-glucose) and (18)F-FDOPA (6-fluoro-((18)F)-L-3, 4-dihydroxyphenylalanine) PET/CT examinations for whole body and brain.

MATERIALS AND METHODS

Three protocols for whole body and three for brain PET/CT were used. The CTDI values were measured using standard head and body CT phantoms and also computed using a software CT-Expo for dose evaluation from the CT component. OLINDA software based on MIRD method was used for estimating doses from the PET component of the PET/CT examination.

RESULTS

The organ doses from (18)F-FDG and (18)F-FDOPA whole body and brain PET/CT studies were estimated. The total effective dose from a typical protocol of whole body PET/CT examination was 14.4 mSv for females and 11.8 mSv for male patients from (18)F-FDG, whereas it was 11 mSv for female and 9.1 mSv for male patients from (18)F-FDOPA. The total effective doses from a typical protocol for PET/CT studies of brain was 6.5 mSv for females and 5.1 mSv for males from (18)F-FDG whereas it was 3.7 mSv for females and 2.8 mSv for males from (18)F-FDOPA.

CONCLUSIONS

The effective radiation doses from whole body PET/CT examination was approximately 4-8 times higher than the background radiation dose from both (18)F-FDG and (18)F-FDOPA scans, while it was 1-3 times the background radiation dose from PET/CT scans of brain.

摘要

目的

估算全身及脑部(18)F-FDG（(18)F-2-脱氧-D-葡萄糖）和(18)F-FDOPA（6-氟-((18)F)-L-3,4-二羟基苯丙氨酸）PET/CT检查对患者特定器官的剂量及有效剂量。

材料与方法

采用了三种全身PET/CT方案和三种脑部PET/CT方案。使用标准头部和体部CT模型测量CTDI值，并使用CT-Expo软件根据CT组件计算剂量以进行剂量评估。基于MIRD方法的OLINDA软件用于估算PET/CT检查中PET组件的剂量。

结果

估算了(18)F-FDG和(18)F-FDOPA全身及脑部PET/CT研究的器官剂量。全身PET/CT检查典型方案中，(18)F-FDG对女性患者的总有效剂量为14.4 mSv，男性患者为11.8 mSv；而(18)F-FDOPA对女性患者为11 mSv，男性患者为9.1 mSv。脑部PET/CT研究典型方案中，(18)F-FDG对女性患者的总有效剂量为6.5 mSv，男性患者为5.1 mSv；而(18)F-FDOPA对女性患者为3.7 mSv，男性患者为2.8 mSv。