基于氟代脱氧葡萄糖正电子发射断层扫描/计算机断层扫描检查中感兴趣区域的肾脏和膀胱剂量估算：一项初步研究。

Estimation of kidneys and urinary bladder doses based on the region of interest in fluorine-fluorodeoxyglucose positron emission tomography/computed tomography examination: a preliminary study.

作者信息

Mustapha Farida Aimi, Bashah Farahnaz Ahmad Anwar, Yassin Ihsan M, Fathinul Fikri Ahmad Saad, Nordin Abdul Jalil, Abdul Razak Hairil Rashmizal

机构信息

Faculty of Health Sciences, Universiti Teknologi MARA Selangor, Selangor, Malaysia.

Faculty of Electrical Engineering, Universiti Teknologi MARA Selangor, Selangor, Malaysia.

出版信息

Quant Imaging Med Surg. 2017 Jun;7(3):310-317. doi: 10.21037/qims.2017.05.03.

DOI:10.21037/qims.2017.05.03

PMID:28811997

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5537126/

Abstract

BACKGROUND

Kidneys and urinary bladder are common physiologic uptake sites of 18fluorine-fluorodeoxyglucose (F-FDG) causing increased exposure of low energy ionizing radiation to these organs. Accurate measurement of organ dose is vital as F-FDG is directly exposed to the organs. Organ dose from F-FDG PET is calculated according to the injected F-FDG activity with the application of dose coefficients established by International Commission on Radiological Protection (ICRP). But this dose calculation technique is not directly measured from these organs; rather it is calculated based on total injected activity of radiotracer prior to scanning. This study estimated the F-FDG dose to the kidneys and urinary bladder in whole body positron emission tomography/computed tomography (PET/CT) examination by comparing dose from total injected activity of F-FDG (calculated dose) and dose from organs activity based on the region of interest (ROI) (measured dose).

METHODS

Nine subjects were injected intravenously with the mean F-FDG dose of 292.42 MBq prior to whole body PET/CT scanning. Kidneys and urinary bladder doses were estimated by using two approaches which are the total injected activity of F-FDG and organs activity concentration of F-FDG based on drawn ROI with the application of recommended dose coefficients for F-FDG described in the ICRP 80 and ICRP 106.

RESULTS

The mean percentage difference between calculated dose and measured dose ranged from 98.95% to 99.29% for the kidneys based on ICRP 80 and 98.96% to 99.32% based on ICRP 106. Whilst, the mean percentage difference between calculated dose and measured dose was 97.08% and 97.27% for urinary bladder based on ICRP 80 while 96.99% and 97.28% based on ICRP 106. Whereas, the range of mean percentage difference between calculated and measured organ doses derived from ICRP 106 and ICRP 80 for kidney doses were from 17.00% to 40.00% and for urinary bladder dose was 18.46% to 18.75%.

CONCLUSIONS

There is a significant difference between calculated dose and measured dose. The use of organ activity estimation based on drawn ROI and the latest version of ICRP 106 dose coefficient should be explored deeper to obtain accurate radiation dose to patients.

摘要

背景

肾脏和膀胱是18氟-氟脱氧葡萄糖（F-FDG）常见的生理性摄取部位，这会使这些器官受到更多低能电离辐射照射。由于F-FDG直接作用于这些器官，准确测量器官剂量至关重要。F-FDG PET的器官剂量是根据注入的F-FDG活度，并应用国际放射防护委员会（ICRP）制定的剂量系数来计算的。但这种剂量计算技术并非直接从这些器官测量得出；而是基于扫描前放射性示踪剂的总注入活度进行计算。本研究通过比较基于F-FDG总注入活度的剂量（计算剂量）和基于感兴趣区（ROI）的器官活度剂量（测量剂量），估算了全身正电子发射断层扫描/计算机断层扫描（PET/CT）检查中肾脏和膀胱的F-FDG剂量。

方法

9名受试者在进行全身PET/CT扫描前静脉注射平均剂量为292.42 MBq的F-FDG。使用两种方法估算肾脏和膀胱剂量，即F-FDG的总注入活度以及基于绘制的ROI的F-FDG器官活度浓度，并应用ICRP 80和ICRP 106中描述的F-FDG推荐剂量系数。

结果

基于ICRP 80，肾脏计算剂量与测量剂量之间的平均百分比差异范围为98.95%至99.29%，基于ICRP 106为98.96%至99.32%。而基于ICRP 80，膀胱计算剂量与测量剂量之间的平均百分比差异为97.08%和97.27%，基于ICRP 106为96.99%和97.28%。然而，ICRP 106和ICRP 80得出的肾脏剂量计算和测量器官剂量之间的平均百分比差异范围为17.00%至40.00%，膀胱剂量为18.46%至18.75%。