Department of Urology, Tianjin Medical University General Hospital, Tianjin, China.
Urology. 2013 Dec;82(6):1336-40. doi: 10.1016/j.urology.2013.08.009. Epub 2013 Oct 13.
To study the significance of measurements of plasma leptin and 5-hydroxytryptamine (5-HT) levels in the diagnosis of premature ejaculation (PE).
We compared plasma leptin and 5-HT levels, intravaginal ejaculation latency time (IELT) and Chinese Index of Premature Ejaculation-5 (CIPE-5) scores between 59 patients with PE and 64 healthy control men without PE. We then analyzed the correlations of plasma leptin and 5-HT levels with the IELT and CIPE-5 scores. The patients with PE were administered sertraline (50mg daily) for 8 weeks, and their plasma leptin and 5-HT levels, CIPE-5 scores and IELT were measured again. Comparative analyses of the data were performed between the experimental and control groups and between the pre- and post-treatment values.
Plasma leptin levels were significantly higher (P <.0001), whereas plasma 5-HT levels (P <.0001), IELT (P <.0001), and CIPE-5 scores (P <.0001) were significantly lower in the experimental group than in the control group. Significant changes in leptin and 5-HT levels, IELT and CIPE-5 scores were observed after treatment in the experimental group. Plasma leptin levels negatively correlated with 5-HT levels, CIPE-5 scores, and IELT, whereas 5-HT levels positively correlated with IELT and CIPE-5 scores.
Plasma leptin and 5-HT levels indicate the presence of PE and can be used as diagnostic markers for PE.
研究血浆瘦素和 5-羟色胺（5-HT）水平测量在早泄（PE）诊断中的意义。
我们比较了 59 例 PE 患者和 64 例无 PE 的健康对照男性的血浆瘦素和 5-HT 水平、阴道内射精潜伏期时间（IELT）和中国早泄指数-5（CIPE-5）评分。然后分析了血浆瘦素和 5-HT 水平与 IELT 和 CIPE-5 评分的相关性。PE 患者给予舍曲林（50mg/d）治疗 8 周，再次测量其血浆瘦素和 5-HT 水平、CIPE-5 评分和 IELT。对实验组和对照组以及治疗前后的数据进行比较分析。
实验组血浆瘦素水平明显升高（P<.0001），而血浆 5-HT 水平（P<.0001）、IELT（P<.0001）和 CIPE-5 评分（P<.0001）明显降低。实验组治疗后瘦素和 5-HT 水平、IELT 和 CIPE-5 评分均有显著变化。血浆瘦素水平与 5-HT 水平、CIPE-5 评分和 IELT 呈负相关，而 5-HT 水平与 IELT 和 CIPE-5 评分呈正相关。
血浆瘦素和 5-HT 水平提示存在 PE，可作为 PE 的诊断标志物。
